Featured Research

from universities, journals, and other organizations

Hormone Therapy Offers Potential Protective Effect Against Colon Cancer In Older Women

Date:
April 27, 2009
Source:
Mayo Clinic
Summary:
Scientists have observed that self-reported use of hormone therapy was associated with a significantly lower colorectal cancer risk. However, the mechanisms for the apparent protective association are still unclear.

In a large study, a national team of researchers led by Mayo Clinic scientists observed that self-reported use of hormone therapy was associated with a significantly lower colorectal cancer risk. However, the mechanisms for the apparent protective association are still unclear.

The study, being presented at the AACR 100th Annual Meeting 2009, was designed to look at possible links between estrogen exposure and colon cancer molecular subtypes, to determine how these hormones might function as anti-cancer agents.

"In our large, prospective study, use of hormone therapy seemed to be beneficial with respect to reducing colorectal cancer risk — women who did use these drugs had a 28 percent lower incidence rate than women who did not use these drugs," says the study's lead author, David Limsui, M.D., a fellow in the Department of Gastroenterology at Mayo Clinic's campus in Rochester, Minn. "But we still don't know how estrogen compounds work in cancer prevention, which is intriguing."

Women who reported using other hormone preparations, such as oral contraceptives, did not appear to derive any colorectal cancer prevention benefits. "Based on our findings, we need to continue exploring the cancer pathways that might be affected by these hormones," Dr. Limsui says.

He adds that other studies have also found that hormone therapy protects postmenopausal women against colon cancer. The largest randomized clinical trial was the 16,000-participant Women's Health Initiative, which concluded in 2004 that combination hormone therapy (estrogen and progestin) reduced a woman's risk of colorectal cancer by about 40 percent, he says. "But few studies have delved deeper to see how these hormones work at the molecular level," Dr. Limsui says.

This investigation is part of the Iowa Women's Health Study, which enrolled 41,836 women from Iowa, aged 55-69, in 1986. After exclusions, the study group consisted of 37,285 women. In the current study, the investigators examined tumor tissue from 553 colorectal cancer patients, specifically looking for associations between self-reported hormone use and a specific DNA methylation pattern, called the CpG island methylator phenotype, or BRAF gene mutations. No associations were detected between hormone use and these molecular markers. Of note, the investigative team previously reported that certain environmental exposures, such as cigarette smoking, might increase colorectal cancer risk through DNA methylation pathways.

The study was funded by a grant from the National Cancer Institute. Researchers from The University of Iowa, the University of Minnesota, the University of Southern California in Los Angeles, the Masonic Cancer Center in Minneapolis and the Fred Hutchinson Cancer Research Center participated in the research.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Hormone Therapy Offers Potential Protective Effect Against Colon Cancer In Older Women." ScienceDaily. ScienceDaily, 27 April 2009. <www.sciencedaily.com/releases/2009/04/090422103552.htm>.
Mayo Clinic. (2009, April 27). Hormone Therapy Offers Potential Protective Effect Against Colon Cancer In Older Women. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2009/04/090422103552.htm
Mayo Clinic. "Hormone Therapy Offers Potential Protective Effect Against Colon Cancer In Older Women." ScienceDaily. www.sciencedaily.com/releases/2009/04/090422103552.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Ebola Cases Could Reach 1.4 Million Within 4 Months

Ebola Cases Could Reach 1.4 Million Within 4 Months

Newsy (Sep. 23, 2014) Health officials warn that without further intervention, the number of Ebola cases in Liberia and Sierra Leone could reach 1.4 million by January. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins