Featured Research

from universities, journals, and other organizations

Commonly Used Ulcer Drugs May Offer Treatment Potential In Alzheimer's Disease

Date:
April 24, 2009
Source:
Elsevier
Summary:
Scientists have discovered that drugs commonly used to treat ulcers have significant neuroprotective properties, which appear to be enhanced when used in combination with ibuprofen, a widely used anti-inflammatory drug.

Scientists at the University of British Columbia have discovered that drugs commonly used to treat ulcers have significant neuroprotective properties, which appear to be enhanced when used in combination with ibuprofen, a widely used anti-inflammatory drug.

"Our results show that proton pump inhibitors are also antiinflammatory agents. They open up an entirely new application for these drugs" said Dr. Sadayuki Hashioka, first author on the paper.

Proton pump inhibitors include lansoprazole and omeprazole. They are remarkably safe drugs which have so far been used only to treat ulcers and other conditions where there is excess gastric acidity. These include Helicobacter pylori infections and side effects from treatment with NSAIDs such as ibuprofen. The finding that they also have anti-inflammatory potential opens up the possibility of using these drugs in a variety of inflammatory conditions where NSAIDs are now used. There would be the double effect of protection from gastrointestinal side effects plus enhanced antiinflammatory activity.

The researchers found that when human microglia, or human monocytic THP-1 cells, were exposed in vitro to the proton pump inhibitors, their secretions became less toxic towards human neuroblastoma cells. In addition, they found that these drugs acted synergistically with ibuprofen, a very widely used antiinflammatory agent. To confirm that the proton pump inhibitors were acting to inhibit inflammation, they found that lansoprazole and omeprazole reduced the secretion from THP-1 cells of the inflammatory cytokine tumor necrosis factor alpha.

Dr. Patrick McGeer, senior investigator on the UBC team, commented "Many epidemiological studies have revealed that individuals on long term treatment with ibuprofen are relatively spared from Alzheimer disease. Our investigation indicates that individuals taking lansoprezole or omeprazole in addition to ibuprofen might be getting even greater protection. It also suggests that a clinical trial of a combination of ibuprofen and a proton pump inhibitor might be effective for those already suffering from Alzheimer disease".

Epidemiological studies might show a sparing effect of Alzheimer disease through the use of proton pump inhibitors alone".

The UBC study was supported by the Pacific Alzheimer Research Foundation.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hashioka et al. Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity. Experimental Neurology, 2009; 217 (1): 177 DOI: 10.1016/j.expneurol.2009.02.002

Cite This Page:

Elsevier. "Commonly Used Ulcer Drugs May Offer Treatment Potential In Alzheimer's Disease." ScienceDaily. ScienceDaily, 24 April 2009. <www.sciencedaily.com/releases/2009/04/090422103556.htm>.
Elsevier. (2009, April 24). Commonly Used Ulcer Drugs May Offer Treatment Potential In Alzheimer's Disease. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/04/090422103556.htm
Elsevier. "Commonly Used Ulcer Drugs May Offer Treatment Potential In Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2009/04/090422103556.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins