Featured Research

from universities, journals, and other organizations

Two 'Types' Of Kidney Tumors Thought To Be Different Diseases Are Actually Variations Of Same Disease

Date:
May 6, 2009
Source:
Van Andel Research Institute
Summary:
Investigators have determined that two types of kidney tumors previously thought to be different diseases are actually variations of the same disease. This finding will help doctors to more accurately diagnose the disease in patients, and demonstrates the importance of using molecular data to diagnose cancer in general.

Van Andel Research Institute (VARI) investigators working in collaboration with Cleveland Clinic researchers have determined that two types of kidney tumors previously thought to be different diseases are actually variations of the same disease. This finding will help doctors to more accurately diagnose the disease in patients, and demonstrates the importance of using molecular data to diagnose cancer in general.

Because adult cystic nephroma (CN) and mixed epithelial and stromal tumors (MEST) produce tumors of differing appearance that include different types of cells, traditionally they have been diagnosed as different diseases. The Cleveland Clinic-VARI study, published recently in The American Journal of Surgical Pathology, demonstrates through molecular analysis that the two types of cancer are variations of the same disease.

“Cancer is often diagnosed by the appearance of the tumor and the types of cells it is made up of,” said VARI Distinguished Scientific Investigator Bin Tean Teh, M.D., Ph.D., one of the authors of the study, “but molecular information can allow us to make the determination that two tumors of dissimilar appearance and cell type are, in fact, the same disease. This has important implications for the diagnosis of cancer in general.”

Both CN and MEST primarily affect middle-aged females. The primary difference between the two is the appearance of the tumors. Researchers compared tissues of CN tumors and MEST to other kidney tumors and normal kidney tissue at the molecular level and found several pieces of evidence that indicated that CN and MEST are the same type of kidney cancer.

“The more data we have, the more we can understand cancer; the more we understand, the better equipped we are to fight it,” said Teh.

“CN and MEST had long been considered as two different entities. Yet some recent studies also suggested they may be the same entity with varying morphology. Such discrepancy caused confusion and frustration among pathologists and urologists. Our study provided by far the most convincing molecular evidence that the two are genetically very similar and should be considered as the same disease entity,” said Cleveland Clinic Anatomic and Clinical Pathologist Ming Zhou, M.D., Ph.D., lead author of the study. “This study is an example of how practicing surgical pathologists could use the molecular tool to improve their diagnostic capability and impact patient care.”


Story Source:

The above story is based on materials provided by Van Andel Research Institute. Note: Materials may be edited for content and length.


Cite This Page:

Van Andel Research Institute. "Two 'Types' Of Kidney Tumors Thought To Be Different Diseases Are Actually Variations Of Same Disease." ScienceDaily. ScienceDaily, 6 May 2009. <www.sciencedaily.com/releases/2009/04/090429120855.htm>.
Van Andel Research Institute. (2009, May 6). Two 'Types' Of Kidney Tumors Thought To Be Different Diseases Are Actually Variations Of Same Disease. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2009/04/090429120855.htm
Van Andel Research Institute. "Two 'Types' Of Kidney Tumors Thought To Be Different Diseases Are Actually Variations Of Same Disease." ScienceDaily. www.sciencedaily.com/releases/2009/04/090429120855.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins