Featured Research

from universities, journals, and other organizations

How Light Fights Psoriasis

Date:
May 9, 2009
Source:
Rockefeller University
Summary:
Ultraviolet light is a proven treatment for psoriasis, one of humanity's oldest known diseases. Sunshine can also beat back the chronic autoimmune disorder of the skin. But explaining light's therapeutic effects has been difficult.

Bright lights. By studying psoriasis patients treated with narrowband ultraviolet light in a light box (above), researchers hope to learn how phototherapy fights the skin disease at the molecular level.
Credit: Image courtesy of Rockefeller University

Ultraviolet light is a proven treatment for psoriasis, one of humanity’s oldest known diseases. Sunshine can also beat back the chronic autoimmune disorder of the skin. But explaining light’s therapeutic effects has been difficult.

Related Articles


“We know it works, but we want to know how,” says Michelle Lowes, an assistant professor of clinical investigation in the Laboratory for Investigative Dermatology at Rockefeller University. “Does it target the pathways that we think are important in the disease?”

A new clinical trial under way at the Center for Clinical and Translational Science in The Rockefeller University Hospital will literally shine light on the disease in hopes of finding out. Researchers, including Lowes and Clinical Research Nurse Practitioner Patricia Gilleaudeau, have recruited the first of what will be 20 patients who will visit the hospital three times a week for up to four months to receive narrowband ultraviolet light B (UVB) treatment. Patients will give skin and blood samples as the treatment takes its course, giving the scientists the possibility to study what is happening at the molecular level as the skin gets better.

UVB therapy is known to kill off T cells, which are partly to blame for the inflammation caused by the disease. For years, Lowes has been systematically accounting for the cell types and proteins involved in the disease. She is specifically interested in whether UVB targets a pathway involving two immune system proteins called cytokines, which she believes may disrupt certain types of T cells and another specialized group of immune-directing dendritic cells. “If we can define the mechanism of action we may potentially have new therapeutic targets for psoriasis and other diseases,” says Lowes, the recipient of a 2008 Doris Duke Charitable Foundation Clinical Scientist Development Award, which is supporting the study.

Doctors often recommend UVB therapy if standard ointment treatments fail and if patients would rather avoid a systemic immunosuppressive drug regimen that has been developed more recently. Patients receive the treatment, brief blasts of UVB, standing inside an upright cabinet whose inside is lined with fluorescent tube lights. The duration of the light exposure increases over the course of the treatment.

Lowes hopes to have some preliminary results in about a year. “We are excited about studying this commonly used therapy for psoriasis with modern methods, and hope that this will lead to a better understanding of this complicated and common skin disease,” she says.


Story Source:

The above story is based on materials provided by Rockefeller University. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University. "How Light Fights Psoriasis." ScienceDaily. ScienceDaily, 9 May 2009. <www.sciencedaily.com/releases/2009/04/090429175930.htm>.
Rockefeller University. (2009, May 9). How Light Fights Psoriasis. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2009/04/090429175930.htm
Rockefeller University. "How Light Fights Psoriasis." ScienceDaily. www.sciencedaily.com/releases/2009/04/090429175930.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins