Featured Research

from universities, journals, and other organizations

Vaccine Slows Progression Of Skeletal Muscle Disorder

Date:
May 14, 2009
Source:
University of California - Irvine
Summary:
A potential vaccine for Alzheimer's disease also has been shown in mice to slow the weakening of muscles associated with inclusion body myositis, a disorder that affects the elderly.

A potential vaccine for Alzheimer's disease also has been shown in mice to slow the weakening of muscles associated with inclusion body myositis, a disorder that affects the elderly.

Related Articles


The finding brings new hope for IBM patients with weakness, inflammation or atrophy of muscles in their fingers, wrists, forearms or quadriceps. There is no cure for IBM, nor is there an effective treatment, according to the National Institutes of Health.

"The immunization wasn't a complete fix, but it significantly slowed the deterioration of motor function in our IBM mice," said Frank LaFerla, director of UC Irvine's Institute for Brain Aging and Dementia. "I hope our discovery leads to clinical trials and, eventually, a vaccine for people suffering from or at risk for IBM.

LaFerla and assistant project scientist Masashi Kitazawa tested the vaccine on 1-year-old mice with high levels of a protein called beta amyloid in their skeletal muscle tissue - a characteristic feature of IBM.

After three months of treatment, the mice were producing antibodies against beta amyloid and had less of the protein in their muscles. Levels of oligomeric beta amyloid - a more toxic form - also were reduced.

"It appears the antibodies helped remove beta amyloid or blocked its accumulation in muscle cells so they could stay healthy longer," Kitazawa said.

Immunotherapy approaches such as vaccination are being extensively studied for Alzheimer's in humans. In that disease, beta amyloid accumulates in the brain and leads to the creation of senile plaques, one of two signature Alzheimer's lesions. Although immunotherapy has shown some benefit in human clinical trials, there are significant safety concerns. For example, about 6 percent of people develop encephalitis, or brain inflammation.

LaFerla thinks it's unlikely IBM patients would develop encephalitis: "With IBM, brain integrity is not compromised like it is with Alzheimer's. We should be cautious, but there's little reason to assume IBM patients would have the same problem."

Study results appear Wednesday, May 13, in The Journal of Neuroscience. UCI scientists Vitaly Vasilevko and David Cribbs also worked on this study, supported by the NIH.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Irvine. "Vaccine Slows Progression Of Skeletal Muscle Disorder." ScienceDaily. ScienceDaily, 14 May 2009. <www.sciencedaily.com/releases/2009/05/090513121210.htm>.
University of California - Irvine. (2009, May 14). Vaccine Slows Progression Of Skeletal Muscle Disorder. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2009/05/090513121210.htm
University of California - Irvine. "Vaccine Slows Progression Of Skeletal Muscle Disorder." ScienceDaily. www.sciencedaily.com/releases/2009/05/090513121210.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins