Featured Research

from universities, journals, and other organizations

Discovery Of Faulty Genes Could Reveal Risk Of Bone Disease

Date:
May 27, 2009
Source:
European Calcified Tissue Society
Summary:
The discovery of faulty genes by researchers in England could help people with Paget's disease, a painful bone condition. Three genes have been found to be associated with the disease which, if detected early enough in people, could hasten diagnosis and treatment.

The discovery of faulty genes by Edinburgh researchers could help people with Paget’s disease, a painful bone condition. Dr Omar Albagha has found three genes associated with the disease which, if detected early enough in people, could hasten diagnosis and treatment.

Paget’s disease affects around three percent of the population over 55 years old in the UK. The carefully regulated system of renewing bone is disrupted. New bone cells (osteoblasts) increase dramatically, are overactive and enlarged causing weak, mis-shapen bones leading to pain deformity, osteoarthritis, fractures and even deafness.

Genetic factors are important but until now, only one gene is known to be linked to one third of the people with Paget’s disease. The research team in the rheumatology section at Edinburgh University wanted to find other gene abnormalities that might predispose people to the disease.

Speaking at the European Symposium on Calcified Tissue in Vienna May 26, Dr Albagha said, “This discovery is important so that we can better understand the development of Paget’s disease and identify those at risk.”

There were 750 patients with Paget’s disease in the study. They did not have the known faulty gene, but 104 of them had a family history of the disease. One thousand healthy people were in the control group. In the analysis of more than 300,000 gene variations covering all known human genes, three genes were found to be associated with Paget’s disease. Further research is now underway to determine how these faults cause the disease.

The damage caused by Paget’s disease is irreversible, but it can be treated. Paracetamol and non-steroidal anti-inflammatory drugs (NSAIDS) relieve the pain, and bisphosphonates help slow down the excessive bone turnover.

“Now we have identified the faulty genes, we will be able to develop ways to screen people ideally in their 30s with a family history of the disease. If necessary, we give them treatment early before the damage is done,” said Dr Albagha.


Story Source:

The above story is based on materials provided by European Calcified Tissue Society. Note: Materials may be edited for content and length.


Cite This Page:

European Calcified Tissue Society. "Discovery Of Faulty Genes Could Reveal Risk Of Bone Disease." ScienceDaily. ScienceDaily, 27 May 2009. <www.sciencedaily.com/releases/2009/05/090526153012.htm>.
European Calcified Tissue Society. (2009, May 27). Discovery Of Faulty Genes Could Reveal Risk Of Bone Disease. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/05/090526153012.htm
European Calcified Tissue Society. "Discovery Of Faulty Genes Could Reveal Risk Of Bone Disease." ScienceDaily. www.sciencedaily.com/releases/2009/05/090526153012.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins