Featured Research

from universities, journals, and other organizations

Predicting Higher Risk For Prostate Cancer Diagnosis

Date:
June 1, 2009
Source:
BioMed Central
Summary:
High-grade prostatic intraepithelial neoplasia (HGPIN) carries a high predictive value for future diagnosis of prostate cancer. New research has shown that 41.8 percent of patients whose extended core biopsy led to an initial diagnosis of HGPIN were subsequently diagnosed with prostate cancer.

High-grade prostatic intraepithelial neoplasia (HGPIN) carries a high predictive value for future diagnosis of prostate cancer. New research has shown that 41.8% of patients whose extended core biopsy led to an initial diagnosis of HGPIN were subsequently diagnosed with prostate cancer.

Paras Singh and Francis Martin, from Lancashire Teaching Hospitals NHS Foundation Trust and Lancaster University, along with their co-workers, conducted a retrospective analysis of the institution's pathology database, investigating the occurrence of prostate cancer in patients initially diagnosed with HGPIN. They also calculated the risk of developing prostate cancer based on initial levels of PSA. They said, "Of 2,192 biopsied patients, there were 88 cases of isolated HGPIN of which 67 patients underwent one or more repeat biopsies. In this repeat-biopsy group, 28 prostate cancer diagnoses were made. Age at first biopsy, higher baseline PSA and higher change in PSA were all predictive of cancer detection on repeat biopsies".

There has been speculation that an initial diagnosis of HGPIN may not be a useful indicator of the future risk of prostate cancer. The authors acknowledge that the 41.8% risk they identified is higher than that found by most contemporary studies, but point out that it is comparable to an earlier US-based study from when there was lower level of PSA screening, perhaps similar to the current situation in the UK.

The researchers conclude, "HGPIN carries a high predictive value for future diagnosis of prostate cancer. Based on our results, we recommend delaying the first repeat biopsy at low PSA range but to have a shorter interval to repeat biopsies at intermediate and higher PSA ranges".


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Paras B Singh, Caroline M Nicholson, Narasimhan Ragavan, Rosemary A Blades, Francis L Martin and Shyam S Matanhelia. Risk of prostate cancer after detection of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) on extended core needle biopsy: a UK hospital experience. BMC Urology, (in press) [link]

Cite This Page:

BioMed Central. "Predicting Higher Risk For Prostate Cancer Diagnosis." ScienceDaily. ScienceDaily, 1 June 2009. <www.sciencedaily.com/releases/2009/05/090526202732.htm>.
BioMed Central. (2009, June 1). Predicting Higher Risk For Prostate Cancer Diagnosis. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/05/090526202732.htm
BioMed Central. "Predicting Higher Risk For Prostate Cancer Diagnosis." ScienceDaily. www.sciencedaily.com/releases/2009/05/090526202732.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins