Featured Research

from universities, journals, and other organizations

Cancer In Humans: Cost Of Being Smarter Than Chimps?

Date:
June 22, 2009
Source:
Georgia Institute of Technology
Summary:
Are the cognitively superior brains of humans, in part, responsible for our higher rates of cancer? A new study comparing the way programmed cell death, or apoptosis, works in humans and chimpanzees suggests there may be something to this puzzling observation.

A new study suggests that humans cognitively superior brains means more instances of cancer compared to chimpanzees.
Credit: iStockphoto/Neal McClimon

Are the cognitively superior brains of humans, in part, responsible for our higher rates of cancer? That's a question that has nagged at John McDonald, chair of Georgia Tech's School of Biology and chief research scientist at the Ovarian Cancer Institute, for a while. Now, after an initial study, it seems that McDonald is on to something. The new study is available online in the journal Medical Hypothesis and will appear in the forthcoming issue of the journal.

Related Articles


"I was always intrigued by the fact that chimpanzees appear to have lower rates of cancer than humans," said McDonald. "So we went back and reanalyzed some previously reported gene expression studies including data that were not used in the original analyses."

McDonald and his graduate students, Gaurav Arora and Nalini Polivarapu, compared chimp-human gene expression patterns in five tissues: brain, testes, liver, kidneys and heart. They found distinct differences in the way apoptosis — or programmed cell death — operates, suggesting that humans do not "self-destroy" cells as effectively as chimpanzees do. Apoptosis is one of the primary mechanisms by which our bodies destroy cancer cells.

"The results from our analysis suggest that humans aren't as efficient as chimpanzees in carrying out programmed cell death. We believe this difference may have evolved as a way to increase brain size and associated cognitive ability in humans, but the cost could be an increased propensity for cancer," said McDonald.

Like all evolutionary hypotheses, this can't be proven absolutely, according to McDonald. However, his lab has recently obtained additional direct experimental evidence consistent with the hypothesis that apoptotic function is more efficient in chimps than in humans.


Story Source:

The above story is based on materials provided by Georgia Institute of Technology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gaurav Arora, Nalini Polavarapu, John F. McDonald. Did natural selection for increased cognitive ability in humans lead to an elevated risk of cancer? Medical Hypotheses, 2009; DOI: 10.1016/j.mehy.2009.03.035

Cite This Page:

Georgia Institute of Technology. "Cancer In Humans: Cost Of Being Smarter Than Chimps?." ScienceDaily. ScienceDaily, 22 June 2009. <www.sciencedaily.com/releases/2009/06/090610091222.htm>.
Georgia Institute of Technology. (2009, June 22). Cancer In Humans: Cost Of Being Smarter Than Chimps?. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2009/06/090610091222.htm
Georgia Institute of Technology. "Cancer In Humans: Cost Of Being Smarter Than Chimps?." ScienceDaily. www.sciencedaily.com/releases/2009/06/090610091222.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.S. Ebola Response Measures Demonstrated

U.S. Ebola Response Measures Demonstrated

AP (Oct. 31, 2014) Officials in the Washington area showed off Ebola response measures being taken at Dulles International Airport and the National Institutes of Health. (Oct. 31) Video provided by AP
Powered by NewsLook.com
Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins