Featured Research

from universities, journals, and other organizations

Breast Cancer Prognosis

Date:
July 26, 2009
Source:
American Journal of Pathology
Summary:
Scientists have identified a stromal marker for breast cancer progression. 

Dr. Arne Östman and colleagues at the Karolinska Institutet in Stockholm have identified a stromal marker for breast cancer progression. 

Related Articles


Platelet-derived growth factor (PDGF) receptors are involved in multiple stages of cancer cell growth. However, the contribution of PDGFR expression in the stroma, or surrounding supportive tissue, of the tumor remains unclear.

Paulsson et al therefore characterized PDGFR expression in stroma of various tumors, including lymphoma and colon, ovarian, prostate, lung, and breast cancer. They found highly variable PDGFR expression in solid tumors, with colon and prostate tumors expressing the highest stromal levels of one type of PDGFR, PDGFβR. In breast cancer, stromal PDGFβR expression in pre-menopausal breast cancer patients significantly correlated with negative prognosis. These data highlight the importance of examining stromal as well as malignant cell expression of PDGF receptors in disease prognosis.

Paulsson et al suggest that "the findings in the present study of robust staining procedures for PDGF receptors should motivate continued studies of the response-predicative value of stromal PDGF receptor status."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin C-H, Bergh J, Brennan DJ, Jirström K, Östman A. Prognostic significance of stromal PDGF %u03B2-receptor expression in human breast cancer. Am J Pathol, 2009, 174: 2752-2764

Cite This Page:

American Journal of Pathology. "Breast Cancer Prognosis." ScienceDaily. ScienceDaily, 26 July 2009. <www.sciencedaily.com/releases/2009/06/090624210847.htm>.
American Journal of Pathology. (2009, July 26). Breast Cancer Prognosis. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2009/06/090624210847.htm
American Journal of Pathology. "Breast Cancer Prognosis." ScienceDaily. www.sciencedaily.com/releases/2009/06/090624210847.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) — Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) — Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins