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New Method To Selectively Kill Metastatic Melanoma Cells Identified

Date:
August 18, 2009
Source:
Virginia Commonwealth University
Summary:
Scientists have identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma -- a cancer that is highly resistant to current treatment strategies.
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An international team of researchers has identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma – a cancer that is highly resistant to current treatment strategies.

Researchers from Virginia Commonwealth University, in collaboration with a team of researchers led by Maria S. Soengas, Ph.D., with the Spanish National Cancer Research Center in Madrid, Spain, found that activation of a specific molecular pathway triggers melanoma cells to begin a process of self-destruction – through self-digestion and programmed cell death. The study is published in the August 4 print issue of the journal Cancer Cell.

“The present research provides a path that could lead with further studies and a phase I clinical trial for safety to the development of a strategy that reenergizes the immune system to destroy this highly aggressive cancer,” said lead investigator at VCU, Paul B. Fisher, M.Ph., Ph.D., the first incumbent of the Thelma Newmeyer Corman Endowed Chair in Cancer Research with the VCU Massey Cancer Center.

According to Fisher, the pathway that is activated involves the melanoma differentiation associated gene-5, or mda-5, a gene initially cloned in Fisher's laboratory, that activates a protein called NOXA that is involved with programmed cell death. This series of chemical reactions results in induction of a cell-killing process involving self-digestion that leads to programmed cell death specifically in melanoma cells. Fisher said that mda-5 is a key regulator of innate immunity that induces interferon beta production limiting replication of specific pathogenic viruses.

This work was supported by grants from the National Institutes of Health, the Spanish Ministry of Science and Innovation, the Spanish Association Against Cancer and the Spanish National Cancer Research Center.

The project team in Spain was led by Soengas, with the Melanoma Laboratory, Molecular Pathology Program, Spanish National Cancer Research Center, Madrid, Spain. Fisher, who also is professor and chair of the Department of Human and Molecular Genetics, and director of the VCU Institute of Molecular Medicine in the VCU School of Medicine, lead the investigative team at VCU which included Paola M. Barral, Ph.D., assistant professor in the Department of Human and Molecular Genetics; and Rupesh Dash, Ph.D., postdoctoral research scientist, in the Department of Human and Molecular Genetics, and the VCU Institute of Molecular Medicine.


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The above post is reprinted from materials provided by Virginia Commonwealth University. Note: Materials may be edited for content and length.


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Virginia Commonwealth University. "New Method To Selectively Kill Metastatic Melanoma Cells Identified." ScienceDaily. ScienceDaily, 18 August 2009. <www.sciencedaily.com/releases/2009/08/090803132742.htm>.
Virginia Commonwealth University. (2009, August 18). New Method To Selectively Kill Metastatic Melanoma Cells Identified. ScienceDaily. Retrieved July 30, 2015 from www.sciencedaily.com/releases/2009/08/090803132742.htm
Virginia Commonwealth University. "New Method To Selectively Kill Metastatic Melanoma Cells Identified." ScienceDaily. www.sciencedaily.com/releases/2009/08/090803132742.htm (accessed July 30, 2015).

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