Featured Research

from universities, journals, and other organizations

Inhibition Of Key Inflammatory Protein, Reduced Radiation Toxicity In Zebrafish

Date:
September 4, 2009
Source:
Thomas Jefferson University
Summary:
Directly inhibiting the activity of a key protein mediator of inflammation reduced radiation toxicity in zebrafish embryos, and may ultimately be of help to patients receiving radiation therapy, according to researchers.

Directly inhibiting the activity of a key protein mediator of inflammation reduced radiation toxicity in zebrafish embryos, and may ultimately be of help to patients receiving radiation therapy, according to researchers from the Kimmel Cancer Center at Jefferson.

Related Articles


Reporting in Molecular Cancer Therapeutics, the researchers found that inhibitors of NF-kappa B not only protected against radiation toxicity when given before exposure to treatment, but also lessened the radiation toxicity when given one to two hours post-exposure.

In the study, both NF-kappa B inhibitors and proteasome inhibitors were examined for their potential to alleviate the negative effects of radiation. However, the proteasome inhibitors tested, which included the FDA-approved bortezomib (Velcade), did not show the same effect. In fact, they actually exacerbated the harmful radiation effects.

"Although proteasome inhibitors demonstrate activity against NF-kappa B, they also target many other pathways," said Ulrich Rodeck, M.D., Ph.D., professor of Dermatology and Cutaneous Biology at Jefferson Medical College of Thomas Jefferson University. "We suspect that these agents may radiosensitize due to inhibition of these other targets."

This study was led by Dr. Rodeck and Adam Dicker, M.D., Ph.D., professor and interim chairman of the department Radiation Oncology at Jefferson.

"We started with the premise that NF-kappa B activity might be helpful in protecting cells against the harmful effects of radiation," Dr. Rodeck said. "We actually found quite the opposite - inhibiting the activity is an advantage that increased the survival in zebrafish and protected the individual organs from harmful effects of radiation."

According to Dr. Rodeck, the key is to downmodulate the NF-kappa B activity, rather than ablating it completely, as excessive NF-kappa B activation is potentially detrimental even in the absence of radiation therapy.

Drs. Rodeck and Dicker will be moving this research forward so that it may ultimately help individuals exposed to "dirty bombs," or cancer patients receiving radiation therapy. Their research team pioneered using zebrafish embryos as a vertebrate model system to investigate the effects of radiation therapy.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Inhibition Of Key Inflammatory Protein, Reduced Radiation Toxicity In Zebrafish." ScienceDaily. ScienceDaily, 4 September 2009. <www.sciencedaily.com/releases/2009/09/090901122633.htm>.
Thomas Jefferson University. (2009, September 4). Inhibition Of Key Inflammatory Protein, Reduced Radiation Toxicity In Zebrafish. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/09/090901122633.htm
Thomas Jefferson University. "Inhibition Of Key Inflammatory Protein, Reduced Radiation Toxicity In Zebrafish." ScienceDaily. www.sciencedaily.com/releases/2009/09/090901122633.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins