Featured Research

from universities, journals, and other organizations

Killing Cancer Like A Vampire Slayer: New Drug Cuts Off Blood Supplies To Starve Cancer Tumors

Date:
September 18, 2009
Source:
American Friends of Tel Aviv University
Summary:
A researcher in Israel has developed a new drug carrier to deliver compounds straight to the cancer tumor, cutting off blood supplies to the tumor and improving the efficacy of anti-cancer drugs.

Like vampires, cancer tumors require an ample supply of blood to stay alive. Without fresh blood for sustenance, cancer cells shrivel up like raisins and die.

To that end, Dr. Ronit Satchi-Fainaro of Tel Aviv University's Department of Physiology and Pharmacology, Sackler School of Medicine, and her team of researchers have developed a new drug carrier to deliver compounds straight to the tumor. Ferrying a variety of existing life-saving therapies right to their target so they can work more effectively, this new invention may alleviate particularly nasty forms of cancers like osteosarcomas and bone metastases. Dr. Satchi-Fainaro believes that her technology can also combat resistance to anti-cancer drugs like Taxol, keeping other normal healthy cells around the tumor safe.

Dr. Satchi-Fainaro, together with two of her doctoral students, Ehud Segal and Keren Miller, has just published papers in the prestigious journals Angewandte Chemie and PLoS ONE on their pre-clinical findings in cellular and animal models using this new discovery.

Fatal attractions

The findings, Dr. Satchi-Fainaro says, could be applied to any tumor type and work to improve the efficacy of today's anti-cancer drugs. "Our two recent studies are on bone cancers and metastasis, and doctors know that most metastasis from breast or prostate cancers to the bone will not respond to chemotherapy. Many times, at this advanced stage of disease, patients are given drugs for palliative rather than curative reasons," she says. "We are out to change that bleak prognosis."

Dr. Satchi-Fainaro's research is based on an understanding of the parasitic behavior of cancer. Most of us have small tumors in our body at all times. They start the size of a pinhead and usually remain at that size as dormant and asymptomatic tumors. Then, at some point, cancer cells proliferate and the tumor grows in mass. At that point the tumor cells migrate to the bones and start recruiting blood vessels using a chemical attractant in order to draw blood for their continued growth in a process called angiogenesis. The researchers looked into the chemical that causes the blood, or endothelial cells, to gravitate to the activated, newly malignant cancer cells.

Living with (instead of dying from) cancer

Armed with this information, "we can turn cancer into a chronic manageable disease," says Dr. Satchi-Fainaro. Her innovative drug delivery system delivers compounds like Taxol known to stop blood vessel growth to cancerous tumors. She bound existing cancer drugs to an inert polymer that doesn't react with the immune system. "Like a stealth airplane," she says, the polymer passes through the body's defense system unnoticed. Then, programmed to find the tumor using the bisphosphonate drug Alendronate, a drug that binds to bones, the carrier delivers its cancer-killing payload.

In animal models, Dr. Satchi-Fainaro found that she was able to reverse the growth of bone cancer tumors. In a second study, she found that loading her polymer with the anti-cancer drug Taxol could inhibit tumor growth by 50%, compared to a Taxol dose that had no effect on tumor growth at all.

Water-soluble and inert, the carrier was found to leak from the blood only at the tumor site. Regular drug formulations diffuse through the whole body, attacking both normal and diseased organs. This makes Dr. Satchi-Fainaro's formulation more effective at targeting tumors. Her new drug also has applications in other diseases involving dysfunctional blood vessel growth, such as diabetes and arthritis.


Story Source:

The above story is based on materials provided by American Friends of Tel Aviv University. Note: Materials may be edited for content and length.


Cite This Page:

American Friends of Tel Aviv University. "Killing Cancer Like A Vampire Slayer: New Drug Cuts Off Blood Supplies To Starve Cancer Tumors." ScienceDaily. ScienceDaily, 18 September 2009. <www.sciencedaily.com/releases/2009/09/090917111621.htm>.
American Friends of Tel Aviv University. (2009, September 18). Killing Cancer Like A Vampire Slayer: New Drug Cuts Off Blood Supplies To Starve Cancer Tumors. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/09/090917111621.htm
American Friends of Tel Aviv University. "Killing Cancer Like A Vampire Slayer: New Drug Cuts Off Blood Supplies To Starve Cancer Tumors." ScienceDaily. www.sciencedaily.com/releases/2009/09/090917111621.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins