Featured Research

from universities, journals, and other organizations

Critical Illness From 2009 H1N1 In Mexico Associated With High Fatality Rate

Date:
October 14, 2009
Source:
JAMA and Archives Journals
Summary:
Critical illness from 2009 influenza A(H1N1) in Mexico occurred among young patients, was associated with severe acute respiratory distress syndrome and shock, and had a fatality rate of about 40 percent, according to a new study.

Critical illness from 2009 influenza A(H1N1) in Mexico occurred among young patients, was associated with severe acute respiratory distress syndrome and shock, and had a fatality rate of about 40 percent, according to a new study.

Related Articles


Novel 2009 influenza A(H1N1) was first reported in the southwestern United States and Mexico in March 2009. Between March 18 and June 1, 2009, 5,029 cases and 97 documented deaths occurred in Mexico. The population and health care system in Mexico City experienced the first and greatest early burden of critical illness, according to background information in the article.

Guillermo Domínguez-Cherit, M.D. of Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán," Mexico City, and colleagues conducted an observational study of critically ill patients at six hospitals in Mexico that treated the majority of such patients with confirmed, probable, or suspected 2009 influenza A(H1N1) between March 24 and June 1, 2009. The study focused on the death rate, rate of critical illness and mechanical ventilation, and length of stay in the hospital and the intensive care unit.

Among 899 patients admitted to hospitals with confirmed, probable, or suspected 2009 influenza A(H1N1), 58 became critically ill. The critically ill patients had a median (midpoint) age of 44 years. Most were treated with antibiotics, and 45 patients were treated with anti-influenza drugs known as neuraminidase inhibitors, including oseltamivir and zanamivir. Fifty-four patients required mechanical ventilation.

"Our analysis of critically ill patients with 2009 influenza A(H1N1) reveals that this disease affected a young patient group," the authors write. "Fever and respiratory symptoms were harbingers of disease in almost all cases. There was a relatively long period of illness prior to presentation to the hospital, followed by a short period of acute and severe respiratory deterioration."

By 60 days, 24 of the critically ill patients (41.4 percent) died. Nineteen patients died within the first two weeks after becoming critically ill.

"Patients who died had greater initial severity of illness, worse hypoxemia [abnormally low levels of oxygen in the blood], higher creatinine kinase levels, higher creatinine levels, and ongoing organ dysfunction," the authors report.

"Early recognition of disease by the consistent symptoms of fever and a respiratory illness during times of outbreak, with prompt medical attention including neuraminidase inhibitors and aggressive support of oxygenation failure and subsequent organ dysfunction, may provide opportunities to mitigate the progression of illness and mortality observed in Mexico," they conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Guillermo Domínguez-Cherit, MD; Stephen E. Lapinsky, MB, BCh, MSc; Alejandro E. Macias, MD; Ruxandra Pinto, PhD(Stat); Lourdes Espinosa-Perez, MD; Alethse de la Torre, MD; Manuel Poblano-Morales, MD; Jose A. Baltazar-Torres, MD; Edgar Bautista, MD; Abril Martinez, MD; Marco A. Martinez, MD; Eduardo Rivero, MD; Rafael Valdez, MD; Guillermo Ruiz-Palacios, MD; Martín Hernández, MD; Thomas E. Stewart, MD; Robert A. Fowler, MD, MS(Epi). Critically Ill Patients With 2009 Influenza A(H1N1) in Mexico. JAMA, 2009;302(17) DOI: 10.1001/jama.2009.1536

Cite This Page:

JAMA and Archives Journals. "Critical Illness From 2009 H1N1 In Mexico Associated With High Fatality Rate." ScienceDaily. ScienceDaily, 14 October 2009. <www.sciencedaily.com/releases/2009/10/091012121339.htm>.
JAMA and Archives Journals. (2009, October 14). Critical Illness From 2009 H1N1 In Mexico Associated With High Fatality Rate. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2009/10/091012121339.htm
JAMA and Archives Journals. "Critical Illness From 2009 H1N1 In Mexico Associated With High Fatality Rate." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012121339.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Newsy (Mar. 6, 2015) — A new study found losing just half an hour of sleep could make you gain weight. Video provided by Newsy
Powered by NewsLook.com
Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) — According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) — Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) — Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins