Featured Research

from universities, journals, and other organizations

Aggressive Microdermabrasion Induces Wound-healing Response In Aging Skin

Date:
October 21, 2009
Source:
JAMA and Archives Journals
Summary:
Microdermabrasion using a coarse diamond-studded instrument appears to induce molecular changes in the skin of older adults that mimic the way skin is remodeled during the wound healing process, according to a new report.

Microdermabrasion using a coarse diamond-studded instrument appears to induce molecular changes in the skin of older adults that mimic the way skin is remodeled during the wound healing process, according to a report in the October issue of Archives of Dermatology, one of the JAMA/Archives journals.

Related Articles


"Microdermabrasion is a popular procedure for skin rejuvenation," the authors write as background information in the article. "It has been suggested that microdermabrasion can improve the appearance of wrinkles, atrophic acne scars, dyspigmentation and other signs of aging skin." The procedure involves buffing the skin using grains of diamond or another hard substance. In order to objectively change the appearance of wrinkled skin, such a procedure would have to induce the production of collagen, the major structural protein in the skin. Previous studies have shown that microdermabrasion using aluminum oxide may not always stimulate collagen production; whether more aggressive but still nonablative (not involving the destruction of skin tissue) methods could consistently do so is unknown.

Darius J. Karimipour, M.D., and colleagues at the University of Michigan, Ann Arbor, conducted a biochemical analysis of skin biopsy specimens before and four hours to 14 days after a microdermabrasion procedure. Forty adults age 50 to 83 years with sun-damaged skin on their arms volunteered to participate in the study. Each underwent microdermabrasion with a diamond-studded handpiece of either a coarse-grit or medium-grit abrasiveness.

When performed with the coarse-grit handpiece, microdermabrasion resulted in the increased production of a wide variety of compounds associated with wound healing and skin remodeling. This includes cytokeratin 16, a well-characterized response to injuries to the skin's outer layer; antimicrobial peptides that fight infection; matrix metalloproteinases that break down skin's structural proteins to allow for rebuilding; and both collagen precursors and other substances that form the pathway to its production.

These molecular changes were not seen in individuals who received microdermabrasion using the medium-grit handpiece, the authors note. All patients experienced a mild period of redness that typically lasted less than two hours.

"We demonstrate that aggressive nonablative microdermabrasion is an effective procedure to stimulate collagen production in human skin in vivo," they write. "The beneficial molecular responses, with minimal downtime, suggest that aggressive microdermabrasion may be a useful procedure to stimulate remodeling and to improve the appearance of aged human skin."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Darius J. Karimipour; Laure Rittie; Craig Hammerberg; Victoria K. Min; John J. Voorhees; Jeffrey S. Orringer; Dana L. Sachs; Ted Hamilton; Gary J. Fisher. Molecular Analysis of Aggressive Microdermabrasion in Photoaged Skin. Archives of Dermatology, 2009; 145 (10): 1114 DOI: 10.1001/archdermatol.2009.231

Cite This Page:

JAMA and Archives Journals. "Aggressive Microdermabrasion Induces Wound-healing Response In Aging Skin." ScienceDaily. ScienceDaily, 21 October 2009. <www.sciencedaily.com/releases/2009/10/091019172107.htm>.
JAMA and Archives Journals. (2009, October 21). Aggressive Microdermabrasion Induces Wound-healing Response In Aging Skin. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2009/10/091019172107.htm
JAMA and Archives Journals. "Aggressive Microdermabrasion Induces Wound-healing Response In Aging Skin." ScienceDaily. www.sciencedaily.com/releases/2009/10/091019172107.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins