Featured Research

from universities, journals, and other organizations

Amphetamine Use In Adolescence May Impair Adult Working Memory

Date:
October 22, 2009
Source:
University of Illinois at Urbana-Champaign
Summary:
Rats exposed to high doses of amphetamines at an age that corresponds to the later years of human adolescence display significant memory deficits as adults -- long after the exposure ends, researchers report.

Rats exposed to high doses of amphetamines at an age that corresponds to the later years of human adolescence display significant memory deficits as adults -- long after the exposure ends, researchers report.

Related Articles


The declines in short-term or "working" memory are most pronounced when the rats are exposed during adolescence, rather than as adults, the researchers found.

"Animals that were given the amphetamine during the adolescent time period were worse at tasks requiring working memory than adult animals that were given the same amount of amphetamine as adults," said psychology professor Joshua Gulley, who led the study with graduate student Jessica Stanis. "This tells us that their working memory capacity has been significantly altered by that pre-exposure to amphetamine."

Gulley and his colleagues will present their findings pn Oct. 21 at the annual meeting of the Society for Neuroscience in Chicago.

The researchers tested two types of amphetamine exposure: intermittent (a steady dose every other day) and "binge-escalation," in which increasing amounts of the drug were given over a period of four days, followed by a simulated binge -- a high dose every two hours for eight hours on the fifth day.

The findings reveal some of the potential long-term consequences of amphetamine abuse by adolescents and also may be relevant to those taking amphetamines for therapeutic purposes, such as for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Gulley cautions that the doses given to the rats are on the high end of what an older, larger adolescent might receive as a therapeutic dose, and that further study is needed to tease out the implications for human health.

The concerns are most robust for adolescents who abuse amphetamines, Gulley said, as they may use much higher doses than those who are prescribed drugs that contain amphetamines.

"Adolescence is a time when the brain is continuing to develop into its mature form, so drug exposure during this critical period could have long-lasting, negative consequences," he said. "Our findings reveal that adolescents are particularly sensitive to the adverse effects of amphetamine on cognitive function and that these effects can persist well after drug use is discontinued."

This research was supported in part by the National Institute of Child Health and Human Development at the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Illinois at Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Urbana-Champaign. "Amphetamine Use In Adolescence May Impair Adult Working Memory." ScienceDaily. ScienceDaily, 22 October 2009. <www.sciencedaily.com/releases/2009/10/091021172655.htm>.
University of Illinois at Urbana-Champaign. (2009, October 22). Amphetamine Use In Adolescence May Impair Adult Working Memory. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2009/10/091021172655.htm
University of Illinois at Urbana-Champaign. "Amphetamine Use In Adolescence May Impair Adult Working Memory." ScienceDaily. www.sciencedaily.com/releases/2009/10/091021172655.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) — Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) — Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) — Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) — Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins