Featured Research

from universities, journals, and other organizations

Chronic Voluntary Alcohol Consumption Impairs Neurogenesis

Date:
October 25, 2009
Source:
Society for Neuroscience
Summary:
A new study found that chronic alcohol consumption reduces the number of new brain cells that form in the hippocampus of adolescent rhesus monkeys. This finding suggests these cells are vulnerable to alcohol and their presence may be essential for preventing alcohol dependence.

A new study found that chronic alcohol consumption reduces the number of new brain cells that form in the hippocampus of adolescent rhesus monkeys. This finding suggests these cells are vulnerable to alcohol and their presence may be essential for preventing alcohol dependence.

The findings were presented at Neuroscience 2009, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.

"We've found a potential mechanism for alcohol's harmful effects on the hippocampus and other brain regions associated with executive function and memory," said Chitra Mandyam, PhD, of the Scripps Research Institute in San Diego and lead author of the study. "This may lead to more effective medications for helping alcoholics overcome their addiction."

In this study, male rhesus monkeys (aged four to five years early in the study and five to six years at the end) were allowed to voluntarily consume a Tang-sweetened solution containing 6 percent alcohol during one-hour sessions, Monday through Friday. A control group of monkeys had similar access to alcohol-free Tang. The alcohol group consumed an average of 1.78 g/kg of alcohol per session.

After five months the primates' brain tissue was analyzed, with careful attention to sections containing the hippocampus for signs of neurogenesis. The researchers found that chronic alcohol consumption significantly altered neurogenesis in the region of the hippocampus that produces self-renewing neural stem cells. Specifically, the alcohol-consuming monkeys exhibited a 58 percent decrease in proliferation -- stem cell birth -- and a 63 percent decrease in differentiation and neurogenesis -- stem cell survival.

"Our results demonstrate that in addition to causing existing cells to degenerate, excessive alcohol keeps new stem cells from forming," Mandyam said.

Research was supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Chronic Voluntary Alcohol Consumption Impairs Neurogenesis." ScienceDaily. ScienceDaily, 25 October 2009. <www.sciencedaily.com/releases/2009/10/091023102314.htm>.
Society for Neuroscience. (2009, October 25). Chronic Voluntary Alcohol Consumption Impairs Neurogenesis. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2009/10/091023102314.htm
Society for Neuroscience. "Chronic Voluntary Alcohol Consumption Impairs Neurogenesis." ScienceDaily. www.sciencedaily.com/releases/2009/10/091023102314.htm (accessed September 20, 2014).

Share This



More Mind & Brain News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Food Addiction Might Be Caused By PTSD

Food Addiction Might Be Caused By PTSD

Newsy (Sep. 18, 2014) New research shows that women who suffer from PTSD are three times more likely to develop a food addiction. Video provided by Newsy
Powered by NewsLook.com
Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins