Featured Research

from universities, journals, and other organizations

Kidney Transplants Generally Safe For Lupus Patients, New Study Suggests

Date:
October 31, 2009
Source:
American Society of Nephrology
Summary:
Individuals with a history of lupus who receive a kidney transplant rarely develop the serious inflammatory condition lupus nephritis in their new organ, according to a new article. The findings indicate that having lupus should not keep individuals from seeking a kidney transplant if they need one. Contrary to previous studies, a new study suggests lupus patients who receive kidney transplants rarely develop lupus nephritis.

Individuals with a history of lupus who receive a kidney transplant rarely develop the serious inflammatory condition lupus nephritis in their new organ, according to a paper being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA. The findings indicate that having lupus should not keep individuals from seeking a kidney transplant if they need one.

Related Articles


Individuals with the autoimmune disease systemic lupus erythematosus (lupus) can experience a number of medical complications, such as lupus nephritis, an inflammatory kidney disorder. Previous studies provide conflicting results about the incidence and severity of lupus nephritis in patients with a history of lupus who have undergone a kidney transplant. Some studies conclude that lupus nephritis is of little consequence while others report that the condition can increase the risk of kidney failure and the risk of death in recipients of a kidney transplant.

Gabriel Contreras, MD, MPH (University of Miami), and his colleagues conducted a thorough evaluation of the frequency of lupus nephritis in kidney transplant recipients and determined the risk this condition has for patients. They mined data from the United Network for Organ Sharing and studied 6850 patients with a history of lupus who received kidney transplants between 1987 and 2006.

The researchers found that lupus nephritis rarely developed in the transplanted kidneys of these lupus patients; it occurred in 2.44% of individuals in the study. When it did occur, lupus nephritis led to a 4-fold increased relative risk of kidney transplant failure; however, the overall risk for the loss of the new organ attributed to lupus developing in the transplanted kidneys was only 7%. During the study period of 19 years, 12.7% of patients died with only 0.4% patients dying in the group with lupus developing in the transplanted kidneys. The investigators also found that African Americans and young women were at higher risk for developing lupus nephritis in their transplanted kidney. Receiving a kidney transplant before or after starting dialysis did not affect one's risk. The type of kidney transplant (deceased vs living donor) also had no effect on a recipient's risk of developing lupus nephritis.

Study co-authors include Baudouin LeClercq (private practice) and Adela. Mattiazzi, Giselle Guerra, Hua Li, Leonardo Tamariz, Cristiane Carvalho, Warren Kupin, Isabel Jaraba, Decio Carvalho, Marco Ladino, and David Roth (University of Miami).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Nephrology. "Kidney Transplants Generally Safe For Lupus Patients, New Study Suggests." ScienceDaily. ScienceDaily, 31 October 2009. <www.sciencedaily.com/releases/2009/10/091031152430.htm>.
American Society of Nephrology. (2009, October 31). Kidney Transplants Generally Safe For Lupus Patients, New Study Suggests. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2009/10/091031152430.htm
American Society of Nephrology. "Kidney Transplants Generally Safe For Lupus Patients, New Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2009/10/091031152430.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins