Featured Research

from universities, journals, and other organizations

Reduced Muscle Strength Associated With Risk For Alzheimer's

Date:
November 10, 2009
Source:
JAMA and Archives Journals
Summary:
Individuals with weaker muscles appear to have a higher risk for Alzheimer's disease and declines in cognitive function over time, according to a new report.

Individuals with weaker muscles appear to have a higher risk for Alzheimer's disease and declines in cognitive function over time, according to a report in the November issue of Archives of Neurology, one of the JAMA/Archives journals.

Alzheimer's disease is characterized by declines in memory and other cognitive (thinking, learning and memory) functions, according to background information in the article. However, it is also associated with other features, such as impaired gait and other motor functions, depression and decreased grip strength.

Patricia A. Boyle, Ph.D., and colleagues at Rush University Medical Center, Chicago, studied 970 older adults (average age 80.3) who did not have dementia at their initial evaluation. Each participant underwent a structured initial evaluation that included a medical history, 21 tests of cognitive function, neurologic and neuropsychological evaluations and a composite measure of muscle strength derived from testing in 11 muscle groups. During an average of 3.6 years of follow-up, each participant completed at least one additional identical evaluation.

Over the study period, 138 participants (14.2 percent) developed Alzheimer's disease. Muscle strength scores ranged from -1.6 to 3.3 units; for each one-unit increase at the beginning of the study, older adults had about a 43 percent decrease in the risk of developing Alzheimer's disease during follow-up. Those at the 90th percentile of muscle strength had about a 61 percent reduced risk of developing Alzheimer's disease compared with those in the 10th percentile.

The association between muscle strength and risk for Alzheimer's disease remained even after other factors, including body mass index and physical activity level, were considered. "Because Alzheimer's disease develops slowly over many years and its hallmark is change in cognitive function, we examined the association of muscle strength with cognitive decline," the authors write. Individuals who were stronger at the beginning of the study experienced a slower rate of decline.

"Finally, in an analysis that excluded participants with dementia or mild cognitive impairment at baseline, muscle strength was associated with the risk of developing mild cognitive impairment, the earliest manifestation of cognitive impairment," the authors write. "Overall, these data show that greater muscle strength is associated with a decreased risk of developing Alzheimer's disease and mild cognitive impairment and suggest that a common pathogenesis may underlie loss of muscle strength and cognition in aging."

The basis for this association is unknown, they note. Possibilities include damage to the mitochondria, which produce energy for the body's cells, that may contribute to loss of both muscle strength and cognitive function. Alternatively, decreased strength could result from stroke or other disorders of the central nervous system that also may reveal subclinical Alzheimer's disease.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Boyle et al. Association of Muscle Strength With the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Community-Dwelling Older Persons. Archives of Neurology, 2009; 66 (11): 1339 DOI: 10.1001/archneurol.2009.240

Cite This Page:

JAMA and Archives Journals. "Reduced Muscle Strength Associated With Risk For Alzheimer's." ScienceDaily. ScienceDaily, 10 November 2009. <www.sciencedaily.com/releases/2009/11/091109173714.htm>.
JAMA and Archives Journals. (2009, November 10). Reduced Muscle Strength Associated With Risk For Alzheimer's. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/11/091109173714.htm
JAMA and Archives Journals. "Reduced Muscle Strength Associated With Risk For Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2009/11/091109173714.htm (accessed October 22, 2014).

Share This



More Mind & Brain News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
Portable Breathalyzer Gets You Home Safely

Portable Breathalyzer Gets You Home Safely

Buzz60 (Oct. 21, 2014) Breeze, a portable breathalyzer, gets you home safely by instantly showing your blood alcohol content, and with one tap, lets you call an Uber, a cab or a friend from your contact list to pick you up. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Your Birth Season Might Determine Your Temperament

Your Birth Season Might Determine Your Temperament

Newsy (Oct. 20, 2014) A new study says the season you're born in can determine your temperament — and one season has a surprising outcome. Video provided by Newsy
Powered by NewsLook.com
Movies Might Desensitize Violence For Parents, Not Just Kids

Movies Might Desensitize Violence For Parents, Not Just Kids

Newsy (Oct. 20, 2014) A study suggests that parents become desensitized to violent movies as well as children, which leads them to allow their kids to view violent films. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins