Featured Research

from universities, journals, and other organizations

Researchers prove key cancer theory: Animal study demonstrates how whole chromosome changes cause cancer

Date:
December 21, 2009
Source:
Mayo Clinic
Summary:
Researchers have proven the longstanding theory that changes in the number of whole chromosomes -- called aneuploidy -- can cause cancer by eliminating tumor suppressor genes.

Mayo Clinic researchers have proven the longstanding theory that changes in the number of whole chromosomes -- called aneuploidy -- can cause cancer by eliminating tumor suppressor genes. Their findings, which appear in the current issue of the journal Cancer Cell along with an independent commentary on the discovery, end a major controversy in the field of cancer research as to whether aneuploidy is a cause or a consequence of cancer.

Related Articles


Virtually all human cancers have an abnormal number of chromosomes. Therefore, it has been long suspected that gene mutations which promote erroneous chromosome separation during cell division are to blame for tumor development. However, because of experimental limitations this was difficult to prove.

"By using a combination of new and established mouse models for human cancer, we were able to prove that aneuploidy causes cancer and elucidate the mechanism by which it does so," explains Jan van Deursen, Ph.D., Mayo Clinic cancer biologist and senior author.

Significance of the Research

These findings explain how chromosomal errors can cause cancer. They prove the role of aneuploidy in the elimination of genes that suppress tumor formation.

"Now that we understand the mechanism by which aneuploidy causes cancer, it will be easier for other researchers to build on this knowledge -- and target new drugs accordingly," says Dr. van Deursen.

Researchers included Darren Baker; Fang Jin, M.D.; and Karthik Jeganathan, all of Mayo Clinic. The research was supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Researchers prove key cancer theory: Animal study demonstrates how whole chromosome changes cause cancer." ScienceDaily. ScienceDaily, 21 December 2009. <www.sciencedaily.com/releases/2009/12/091207123107.htm>.
Mayo Clinic. (2009, December 21). Researchers prove key cancer theory: Animal study demonstrates how whole chromosome changes cause cancer. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2009/12/091207123107.htm
Mayo Clinic. "Researchers prove key cancer theory: Animal study demonstrates how whole chromosome changes cause cancer." ScienceDaily. www.sciencedaily.com/releases/2009/12/091207123107.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins