Featured Research

from universities, journals, and other organizations

Kidney injury in hospital increases long-term risk of death, study finds

Date:
December 21, 2009
Source:
American Society of Nephrology
Summary:
Patients with sudden loss of kidney function, called acute kidney injury, are more likely to die prematurely after leaving the hospital -- even if their kidney function has apparently recovered, according to new research.

Patients with sudden loss of kidney function, called acute kidney injury (AKI), are more likely to die prematurely after leaving the hospital -- even if their kidney function has apparently recovered, according to an upcoming study in Journal of the American Society of Nephrology (JASN).

"Our study found that risk of death remains elevated long after the acute kidney injury," comments Jean-Phillipe Lafrance, MD (Center for Health Quality, Outcomes, and Economic Research, Bedford, MA).

Lafrance, along with Donald R. Miller, ScD (also of Center for Health Quality, Outcomes, and Economic Research), used a Veterans Affairs health database to analyze long-term outcomes in about 83,000 veterans with AKI (previously called acute renal failure). Patients with AKI have rapid deterioration in kidney function, resulting from many possible causes. More than half of patients with AKI need dialysis at least temporarily, and many die prior to leaving the hospital. The new study focused on AKI patients who did not need dialysis and who survived at least three months after leaving the hospital.

During an average two year follow-up, 30 percent of the AKI patients died compared to 16 percent of a group of patients without AKI. Researchers determined risk of death to be about 40 percent higher in the AKI group, even after adjusting for other factors including impaired kidney function following hospital discharge.

The risk was even higher for patients with more severe AKI, as defined by severe declines in kidney function. Mortality risk was elevated even for patients whose kidney function returned to normal after AKI, as it did in more than half of cases. "Impaired kidney function following hospital discharge explained only part of the increased long-term mortality risk associated with AKI," said Lafrance.

The study had several limitations: it used data collected for another purpose, did not include complete information on the serum creatinine test used to diagnose AKI, was mostly limited to men, and did not include information on causes of death. It also lacked data on the long-term risk of chronic kidney disease, a potential late complication of AKI.

Nephrologists have known that AKI is associated with a high risk of death in the hospital, but it has been unclear if this risk persists after the patient goes home. "Better understanding of the long-term outcomes after AKI may inform further studies and improve patient care after those events," Lafrance added.

The study was supported by a VA research grant. Dr. Lafrance was supported by a KRESCENT Fellowship award. Dr. Miller has received research grant funds from Sanofi-Aventis.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lafrance et al. Acute Kidney Injury Associates with Increased Long-Term Mortality. Journal of the American Society of Nephrology, 2009; (in press) DOI: 10.1681/ASN.2009060636

Cite This Page:

American Society of Nephrology. "Kidney injury in hospital increases long-term risk of death, study finds." ScienceDaily. ScienceDaily, 21 December 2009. <www.sciencedaily.com/releases/2009/12/091217183051.htm>.
American Society of Nephrology. (2009, December 21). Kidney injury in hospital increases long-term risk of death, study finds. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2009/12/091217183051.htm
American Society of Nephrology. "Kidney injury in hospital increases long-term risk of death, study finds." ScienceDaily. www.sciencedaily.com/releases/2009/12/091217183051.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins