Featured Research

from universities, journals, and other organizations

Most plentiful cell type in the heart -- the fibroblast -- contributes to heart failure

Date:
December 22, 2009
Source:
Journal of Clinical Investigation
Summary:
Fibroblasts are the most numerous cell type in the heart, but they are considered to have a less important role in heart failure than heart muscle cells. However, a team of researchers has now determined that fibroblasts are essential for the response of the mouse heart to conditions that mimic high blood pressure, a response that if sustained ultimately leads to heart failure.

Fibroblasts are the most numerous cell type in the heart, but they are considered to have a less important role in heart failure than heart muscle cells. However, a team of researchers, at the University of Tokyo Graduate School of Medicine, Japan, has now determined that fibroblasts are essential for the response of the mouse heart to conditions that mimic high blood pressure, a response that if sustained ultimately leads to heart failure.

The research appears in the Journal of Clinical Investigation.

The team, led by Ryozo Nagai and Ichiro Manabe, showed that mice lacking Klf5 only in heart muscle cells mounted a normal response to conditions designed to mimic moderate increases in blood pressure, whereas mice lacking Klf5 only in fibroblasts in the heart failed to respond to such conditions. Surprisingly, mice lacking Klf5 only in fibroblasts in the heart developed more severe heart failure than normal mice and died when subjected to conditions designed to mimic extreme increases in blood pressure.

The authors therefore conclude that fibroblasts in the heart have a central role in the response of the heart to changes in blood pressure and suggest that modulating their function might provide a way to treat individuals with heart failure.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Norifumi Takeda, Ichiro Manabe, Yuichi Uchino, Kosei Eguchi, Sahohime Matsumoto, Satoshi Nishimura, Takayuki Shindo, Motoaki Sano, Kinya Otsu, Paige Snider, Simon J. Conway and Ryozo Nagai. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI40295

Cite This Page:

Journal of Clinical Investigation. "Most plentiful cell type in the heart -- the fibroblast -- contributes to heart failure." ScienceDaily. ScienceDaily, 22 December 2009. <www.sciencedaily.com/releases/2009/12/091221215810.htm>.
Journal of Clinical Investigation. (2009, December 22). Most plentiful cell type in the heart -- the fibroblast -- contributes to heart failure. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2009/12/091221215810.htm
Journal of Clinical Investigation. "Most plentiful cell type in the heart -- the fibroblast -- contributes to heart failure." ScienceDaily. www.sciencedaily.com/releases/2009/12/091221215810.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins