Featured Research

from universities, journals, and other organizations

Starting out early: Role of the molecule RANTES in arterial blood vessel injury

Date:
December 28, 2009
Source:
Journal of Clinical Investigation
Summary:
Damage to the wall of arterial blood vessels leads to the formation of structures known as neointimal lesions. If these structures do not resolve, they cause narrowing of the blood vessel, which leads to oxygen deprivation in the tissues fed by the blood vessels and subsequent tissue and organ damage.

Damage to the wall of arterial blood vessels leads to the formation of structures known as neointimal lesions. If these structures do not resolve, they cause narrowing of the blood vessel, which leads to oxygen deprivation in the tissues fed by the blood vessels and subsequent tissue and organ damage.

Manfred Boehm and colleagues, at the National Institutes of Health, Bethesda, have now identified some of the early events that occur immediately after arterial blood vessel damage in the mouse, providing information about a stage of the response to arterial blood vessel injury not previously well understood.

The research appears in the Journal of Clinical Investigation.

In the study, when mouse arterial blood vessels were subject to damage, cells in the blood vessel wall known as vascular smooth muscle cells (VSMCs) upregulated expression of a protein known as RANTES. The RANTES was secreted by the VSMCs and attracted inflammatory cells known as T cells and macrophages to the region of arterial blood vessel damage.

Detailed analysis revealed that VSCM expression of RANTES was triggered by the molecule TNF-alpha and was dependent on the gene regulatory molecules STAT3 and NF-kappa-B. Consistent with this, both mice lacking TNF-alpha and mice lacking STAT3 in VSMCs produced less RANTES after arterial blood vessel damage than did normal mice.

The importance of these data are highlighted and put into the context of the bigger picture of arterial blood vessel damage in an accompanying commentary by Timothy Hla and Myat Lin Oo, at Weill Medical College of Cornell University, New York.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Jason C. Kovacic, Rohit Gupta, Angela C. Lee, Mingchao Ma, Fang Fang, Claire N. Tolbert, Avram D. Walts, Leilani E. Beltran, Hong San, Guibin Chen, Cynthia St. Hilaire and Manfred Boehm. STAT3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. Journal of Clinical Investigation, Published December 28, 2009 DOI: 10.1172/JCI40364
  2. Timothy Hla and Myat Lin Oo. Ramping up RANTES in the acute response to arterial injury. Journal of Clinical Investigation, 2010; 120 (1): 90-92 DOI: 10.1172/JCI41738

Cite This Page:

Journal of Clinical Investigation. "Starting out early: Role of the molecule RANTES in arterial blood vessel injury." ScienceDaily. ScienceDaily, 28 December 2009. <www.sciencedaily.com/releases/2009/12/091228171938.htm>.
Journal of Clinical Investigation. (2009, December 28). Starting out early: Role of the molecule RANTES in arterial blood vessel injury. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2009/12/091228171938.htm
Journal of Clinical Investigation. "Starting out early: Role of the molecule RANTES in arterial blood vessel injury." ScienceDaily. www.sciencedaily.com/releases/2009/12/091228171938.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins