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Tiotropium associated with reduced mortality in patients with COPD

Date:
January 11, 2010
Source:
American College of Chest Physicians
Summary:
New research suggests that tiotropium, a long-acting anticholinergic used in patients with COPD, may be associated with a reduction in all-cause mortality, cardiovascular mortality, and cardiovascular events.
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New research suggests that tiotropium, a long-acting anticholinergic used in patients with COPD, may be associated with a reduction in all-cause mortality, cardiovascular mortality, and cardiovascular events.

Researchers from Caritas-St. Elizabeth Medical Center in Boston, MA, reviewed the outcomes of 30 completed clinical trials in the tiotropium project database. Within the trials, 10,846 patients were treated with tiotropium and 8,699 patients received a placebo.

Results indicated that patients treated with tiotropium had lower incidence rates (IR) of all-cause mortality, cardiovascular mortality, and cardiovascular events (IR = 3.44, .91, and 2.15 per 100 patients, respectively), compared with placebo (IR = 4.10, 1.24, and 2.67, respectively). Within the tiotropium group, the overall risk for serious or fatal lower respiratory events also was reduced.

The mechanism by which tiotropium may reduce cardiovascular mortality is unclear, but researchers speculate that there may be an association with the reduction in respiratory events.

The article is published in the January issue of Chest, the peer-reviewed journal of the American College of Chest Physicians.


Story Source:

The above story is based on materials provided by American College of Chest Physicians. Note: Materials may be edited for content and length.


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American College of Chest Physicians. "Tiotropium associated with reduced mortality in patients with COPD." ScienceDaily. ScienceDaily, 11 January 2010. <www.sciencedaily.com/releases/2010/01/100105183723.htm>.
American College of Chest Physicians. (2010, January 11). Tiotropium associated with reduced mortality in patients with COPD. ScienceDaily. Retrieved May 26, 2015 from www.sciencedaily.com/releases/2010/01/100105183723.htm
American College of Chest Physicians. "Tiotropium associated with reduced mortality in patients with COPD." ScienceDaily. www.sciencedaily.com/releases/2010/01/100105183723.htm (accessed May 26, 2015).

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