Featured Research

from universities, journals, and other organizations

Low growth hormone levels linked to memory defects later in life can be prevented with early growth hormone treatment

Date:
January 13, 2010
Source:
Society for Endocrinology
Summary:
Scientists have shown that early growth hormone supplementation in rats with growth hormone deficiency can prevent defects in memory developing later in adulthood. The study is the first to show that memory defects in adults as a result of growth hormone deficiency arising in childhood can be prevented by growth hormone treatment during adolescence.

Scientists have shown that early growth hormone supplementation in rats with growth hormone deficiency can prevent defects in memory developing later in adulthood. The study, published in the Journal of Endocrinology, is the first to show that memory defects in adults as a result of growth hormone deficiency arising in childhood can be prevented by growth hormone treatment during adolescence.

Related Articles


Growth hormone levels start off low in early life, and peak just before puberty, after which they gradually decline with increasing age. Growth hormone deficiency can be present from birth, or arise during childhood or adulthood as a result of various disorders. Growth hormone deficiency originating in childhood is treated with growth hormone supplementation to increase body size (mainly height) during adolescence. Until now, it has not been clear if or how this treatment directly affects memory in adulthood, or whether it can prevent learning and memory deficits commonly observed in adults with childhood onset growth hormone deficiency.

Professor Michelle Nicolle and colleagues from Wake Forest University School of Medicine and The Reynolds Oklahoma Center on Aging (University of Oklahoma Health Sciences Center), USA studied rats with a genetic mutation that leads them to produce significantly decreased levels of growth hormone, as a model for early-onset growth hormone deficiency. They assessed the animals' performance in a water maze test designed to measure spatial memory, at either 8 or 18 months of age. To mimic adult-onset growth hormone deficiency, one group was treated with growth hormone for a specific period during adolescence (4-14 weeks old) only; to mimic childhood-onset growth hormone deficiency, one group was treated with a saline control; and a third group was treated with growth hormone from 4 weeks old throughout their lifespan. The above groups were compared to a control group with normal growth hormone levels.

At 8 months old there was no difference between the groups in performance in the water maze task. However, at 18 months of age, the group with childhood-onset growth hormone deficiency performed significantly poorer in the task than all other groups, indicating poorer spatial learning. This suggests that the growth hormone supplementation during adolescence prevented the age-related deficiencies in learning and memory seen in the childhood-onset group. The group treated with growth hormone during puberty (adult-onset) performed equally well as the group treated with growth hormone into adulthood, indicating no further effect of growth hormone treatment on spatial memory beyond adolescence.

These results show that, in rats, memory impairment in adults as a result of growth hormone deficiency arising in childhood can be reduced or prevented by early growth hormone supplementation. This study highlights the potentially significant role that growth hormone plays in memory function and the importance of further studies with larger sample sizes to determine the mechanisms underlying the effects of growth hormone treatment during adolescence on brain maturation.

Researcher Professor Michelle Nicolle said: "We carried out this study to investigate the effect of growth hormone supplementation during adolescence on memory function in adults. Our results show that in rats, growth hormone deficiency during adolescence leads to learning and memory deficits in adults. Furthermore, treating growth hormone deficiency by supplementing with growth hormone during puberty prevents this deleterious effect on brain function later in life. This shows that growth hormone replacement during adolescence is important not only for increasing growth but also for brain maturation. This may have important implications for the treatment of patients with growth hormone deficiency and is an aspect of therapy that needs to be taken into account in future clinical growth hormone studies in this key age group."


Story Source:

The above story is based on materials provided by Society for Endocrinology. Note: Materials may be edited for content and length.


Journal Reference:

  1. E Nieves-Martinez, W E Sonntag, A Wilson, A Donahue, D P Molina, J Brunso-Bechtold, and M M Nicolle. Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. Journal of Endocrinology, 2010; 204 (1): 31 DOI: 10.1677/JOE-09-0323

Cite This Page:

Society for Endocrinology. "Low growth hormone levels linked to memory defects later in life can be prevented with early growth hormone treatment." ScienceDaily. ScienceDaily, 13 January 2010. <www.sciencedaily.com/releases/2010/01/100112213106.htm>.
Society for Endocrinology. (2010, January 13). Low growth hormone levels linked to memory defects later in life can be prevented with early growth hormone treatment. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2010/01/100112213106.htm
Society for Endocrinology. "Low growth hormone levels linked to memory defects later in life can be prevented with early growth hormone treatment." ScienceDaily. www.sciencedaily.com/releases/2010/01/100112213106.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins