Featured Research

from universities, journals, and other organizations

Small clusters of islet amyloid polypeptides may contribute to diabetes

Date:
January 27, 2010
Source:
American Journal of Pathology
Summary:
Researchers have discovered that small clusters (oligomers) of islet amyloid polypeptides (IAPPs) may contribute to the onset of type 2 diabetes mellitus.

A group led by Dr. Peter C. Butler of the University of California, Los Angeles, CA has discovered that small clusters (oligomers) of islet amyloid polypeptides (IAPPs) may contribute to the onset of type 2 diabetes mellitus.

These results are presented in the February 2010 issue of The American Journal of Pathology.

Type 2 diabetes, or non-insulin-dependent diabetes, is characterized by high blood glucose in the presence of insulin resistance. Rates of diabetes doubled in the United States between 1990 and 2005, with nearly 23.6 million people diagnosed with diabetes.

In patients with type 2 diabetes, beta cells, the cells in the pancreas that secrete insulin, are progressively lost, and this loss is often associated with the accumulation of misfolded proteins, in particular IAPP. Similar amyloid protein accumulation has been implicated in the pathogenesis of diverse neurodegenerative diseases including Alzheimer, Parkinson's, and Huntington's disease. Gurlo et al explored the role of IAPP amyloids in type 2 diabetes pathology. They discovered that small clusters (oligomers) of IAPP formed within the beta cells and disrupted the membranes required for insulin secretion. These oligomers were also found in beta cells in human patients with type 2 diabetes. Moreover, IAPP oligomers also disrupted mitochondrial membranes, which can result in beta cell death.

Gurlo et al suggest that "IAPP toxic oligomers form within the secretory pathway in beta cells, to an increased extent in [type 2 diabetes] and as a function of obesity. … Taking the present study along with the known properties of toxic IAPP oligomers to induce membrane damage, we conclude that toxic oligomers may contribute to the beta cell dysfunction and apoptosis characteristic of type 2 diabetes."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gurlo T, Ryazantsev S, Huang C-j, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe TG, Butler PC. Evidence for Proteotoxicity in beta-cells in Type 2 Diabetes, Toxic Islet Amyloid Polypeptide Oligomers form Intracellularly in the Secretory Pathway. American Journal of Pathology, 2010; 176: 861-869 DOI: 10.2353/ajpath.2010.090532

Cite This Page:

American Journal of Pathology. "Small clusters of islet amyloid polypeptides may contribute to diabetes." ScienceDaily. ScienceDaily, 27 January 2010. <www.sciencedaily.com/releases/2010/01/100122003104.htm>.
American Journal of Pathology. (2010, January 27). Small clusters of islet amyloid polypeptides may contribute to diabetes. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2010/01/100122003104.htm
American Journal of Pathology. "Small clusters of islet amyloid polypeptides may contribute to diabetes." ScienceDaily. www.sciencedaily.com/releases/2010/01/100122003104.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins