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Vaccine design: Three is better than two when boosting vaccine effectiveness

Date:
February 1, 2010
Source:
Journal of Clinical Investigation
Summary:
To boost vaccine effectiveness molecules known as adjuvants are often included in the vaccine formulation. Adjuvants are most commonly used to increase the magnitude of vaccine-induced immune responses, specifically T cell immune responses. However, the quality of a T cell response can be more important than its quantity, and a team of researchers has now identified a way to increase the quality but not the quantity of a vaccine-induced T cell response in mice.

To boost vaccine effectiveness molecules known as adjuvants are often included in the vaccine formulation. Adjuvants are most commonly used to increase the magnitude of vaccine-induced immune responses, specifically T cell immune responses. However, the quality of a T cell response can be more important than its quantity, and a team of researchers, at the National Institutes of Health, has now identified a way to increase the quality but not the quantity of a vaccine-induced T cell response in mice.

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TLRs are a family of microorganism-sensing proteins that represent potential new vaccine adjuvants, as stimulating certain pairs of TLRs has a synergistic effect on the magnitude of immune responses in preclinical models. The team, led by Jay Berzofsky, found that when mice were immunized with an HIV peptide together with three molecules that bound different TLRs they mounted a more effective protective T cell response than did mice immunized with the HIV peptide together with any two of the ligands.

Further analysis determined that the increased protection correlated with T cell responses of enhanced quality, rather than enhanced quantity.

The authors therefore suggest that select TLR ligand combinations could be used to separately manipulate the quality and quantity of vaccine-induced T cell responses.



Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zhu et al. Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI39293

Cite This Page:

Journal of Clinical Investigation. "Vaccine design: Three is better than two when boosting vaccine effectiveness." ScienceDaily. ScienceDaily, 1 February 2010. <www.sciencedaily.com/releases/2010/01/100125213238.htm>.
Journal of Clinical Investigation. (2010, February 1). Vaccine design: Three is better than two when boosting vaccine effectiveness. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2010/01/100125213238.htm
Journal of Clinical Investigation. "Vaccine design: Three is better than two when boosting vaccine effectiveness." ScienceDaily. www.sciencedaily.com/releases/2010/01/100125213238.htm (accessed October 31, 2014).

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