Featured Research

from universities, journals, and other organizations

Rotavirus vaccine offers new tool to combat severe diarrhea in developing world

Date:
January 28, 2010
Source:
University of Liverpool
Summary:
Diarrhea caused by rotavirus infection could be significantly reduced in the developing world with the use of a vaccine to prevent the condition according to new research.

Rotavirus is the leading cause of severe, acute gastroenteritis among infants and young children throughout the world and is responsible for an estimated 527,000 deaths among children under five each year. More than 90% of childhood deaths attributed to rotavirus infection occur in developing countries. Symptoms include severe diarrhoea and vomiting, leading to loss of fluid and electrolytes which can result in dehydration, shock, and death.

Safety and efficacy trials have already been conducted with two new rotavirus vaccines in Europe and the Americas which found they were more than 90% effective in preventing severe rotavirus gastroenteritis, but until now, no trials had been carried out in Africa or Asia, where the burden of disease is greatest.

One of the rotavirus vaccines -- Rotarix, developed by GlaxoSmithKline Biologicals (GSK) -- was tested in the Phase III clinical trial in Malawi and South Africa, which found that the vaccine reduced the overall incidence of severe rotavirus diarrhoea by 61.2%, although vaccine efficacy was lower in Malawi (49.4%) compared with South Africa (76.9%). The vaccine was able to prevent more rotavirus diarrhoea episodes in Malawi because of a higher rate of severe disease in the country. The new data informed a recent global recommendation of rotavirus vaccine by the World Health Organisation (WHO).

Dr Nigel Cunliffe, Reader in Medical Microbiology at the University of Liverpool, who led the study team in Malawi, said: "These data show for the first time that rotavirus vaccination can prevent severe diarrhoea in an African setting, where almost half of the total global burden of rotavirus deaths occurs.

"They demonstrate the large impact that rotavirus vaccines could have in countries with high diarrhoeal disease burden when introduced into their national childhood immunisation schedules."

The study in Malawi was conducted through a public-private partnership that included the University of Liverpool, University of Malawi College of Medicine, GAVI, PATH and GSK. Dr Cunliffe has investigated the disease burden and epidemiology of rotavirus infection in Malawi since 1997 in studies funded by The Wellcome Trust, the WHO and GSK.

The research is published in the New England Journal of Medicine.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Cite This Page:

University of Liverpool. "Rotavirus vaccine offers new tool to combat severe diarrhea in developing world." ScienceDaily. ScienceDaily, 28 January 2010. <www.sciencedaily.com/releases/2010/01/100127182456.htm>.
University of Liverpool. (2010, January 28). Rotavirus vaccine offers new tool to combat severe diarrhea in developing world. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2010/01/100127182456.htm
University of Liverpool. "Rotavirus vaccine offers new tool to combat severe diarrhea in developing world." ScienceDaily. www.sciencedaily.com/releases/2010/01/100127182456.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins