Featured Research

from universities, journals, and other organizations

'Silent strokes' linked to kidney failure in diabetics

Date:
January 28, 2010
Source:
American Society of Nephrology
Summary:
In patients with type 2 diabetes, silent cerebral infarction -- small areas of brain damage caused by injury to small blood vessels -- signals an increased risk of progressive kidney disease and kidney failure, according to a new study.

In patients with type 2 diabetes, silent cerebral infarction (SCI) -- small areas of brain damage caused by injury to small blood vessels -- signals an increased risk of progressive kidney disease and kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN).

Related Articles


If SCI is present in the brain, it could be an indicator that small-vessel damage is present in the kidneys as well, suggests the new study by Takashi Uzu, MD (Shiga University School of Medicine, Otsu, Japan). Uzu comments, "Silent cerebral infarction may be a new marker to identify patients who are risk for declining kidney function."

The study included 608 patients with type 2 diabetes, all initially free of symptomatic stroke, heart disease, or kidney disease (overt proteinuria or renal dysfunction). On magnetic resonance imaging (MRI) scans of the brain, 177 of the patients (29 percent) had SCI -- subtle areas of brain damage caused by disease of the brain blood vessels, but not severe enough to cause overt symptoms of stroke.

At long-term follow-up, diabetic patients with SCI had higher risks of progressive kidney disease. Compared to those with normal brain MRI scans, patients with SCI were about 2.5 times more likely to die or develop end-stage kidney disease. Their risk of declining kidney function or dialysis was nearly five times higher.

New approaches are needed to assess the risk of diabetes-related kidney disease. "Microalbuminuria -- small amounts of the protein albumin in urine -- is the most important marker to predict the progression of kidney disease in diabetic patients," explains Uzu. "However, decreased kidney function without microalbuminuria is common in patients with type 2 diabetes."

The new study shows that diabetic patients with subtle brain damage detected on MRI scans are more likely to develop serious kidney disease, independent of microalbuminuria. "Evaluating both SCI and microalbuminuria may be useful for determining the risk of progression of kidney disease in diabetic patients," says Uzu.

The study had some risk of bias related to patient selection. Also, although most of the patients with SCI had multiple small areas of brain damage, the study did not exclude patients with relatively large areas of brain damage. "Therefore, not only small vessel disease but also relatively large vessel disease might have affected the progression of kidney disease in our patients," adds Uzu.

Study co-authors include Yasuo Kida (The Second Okamoto Hospital), Nobuo Shirahashi (Osaka City University), Tamaki Harada (Higashi-Osaka City Hospital), Atsushi Yamauchi, Makoto Nomura, (Osaka Rosai Hospital), Keiji Isshiki Shin-ichi Araki, Toshiro Sugimoto, (Shiga University of Medical Science), Daisuke Koya (Kanazawa Medical University), Masakazu Haneda (Asahikawa Medical Colledge), Atsunori Kashiwagi, and Ryuichi Kikkwa (Shiga University of Medical Science).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yasuo Kida et al. Cerebral Microvascular Disease Predicts Renal Failure in Type 2 Diabetes. Journal of the American Society Nephrology, January 28, 2010 DOI: 10.1681/ASN.2009050558

Cite This Page:

American Society of Nephrology. "'Silent strokes' linked to kidney failure in diabetics." ScienceDaily. ScienceDaily, 28 January 2010. <www.sciencedaily.com/releases/2010/01/100128171814.htm>.
American Society of Nephrology. (2010, January 28). 'Silent strokes' linked to kidney failure in diabetics. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2010/01/100128171814.htm
American Society of Nephrology. "'Silent strokes' linked to kidney failure in diabetics." ScienceDaily. www.sciencedaily.com/releases/2010/01/100128171814.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins