Featured Research

from universities, journals, and other organizations

Estrogen-only hormone replacement therapy may increase risk of asthma after menopause

Date:
February 8, 2010
Source:
BMJ-British Medical Journal
Summary:
Estrogen-only hormone replacement therapy may increase the risk of developing asthma after the menopause, suggests a large scale study.

Oestrogen-only hormone replacement therapy (HRT) may increase the risk of developing asthma after the menopause, suggests a large scale study published ahead of print in the journal Thorax.

The authors base their findings on 57, 664 women, who were quizzed about their use of HRT and development of asthma symptoms every two years between 1990 and 2002.

All the women were taking part in the French E3N study, which includes almost 100, 000 women born between 1925 and 1950, and is the French component of the European Prospective Investigation into Cancer and Nutrition (EPIC).

None of these women had asthma when menopausal symptoms began.

The monitoring period equated to 495,448 person years in all, of which over a third was accounted for by women who had not used HRT (35.7%).

Previous users made up 4.5% while information on how long HRT was used was not known for a further 4%. Of the remainder, just under 56% were recent users of HRT.

Between 1990 and 2002, 569 women were newly diagnosed with asthma, corresponding to a rate of 1.15 cases per 1000 women a year.

Compared with women who had never used any form of HRT, those who did use it were 21% more likely to develop asthma, after adjusting for factors likely to influence the results.

Almost one in 10 women with a natural menopause (9.4%), and more than one in four (28%) of those with a surgically induced menopause, used HRT containing oestrogen alone.

The risk of asthma was significant only among those using oestrogen alone. Among these women the overall risk of asthma was 54% higher than among those who had never used any form of HRT.

Oestrogen only users who had never smoked and those who had had some form of allergy before their asthma diagnosis were at greatest risk of developing asthma -- 80% and 86% higher, respectively.

A small increased risk for asthma was also seen in women using combined oestrogen and progesterone HRT who were either non smokers or who had had some form of allergic reaction in the past.

Previous research has suggested that female hormones may have a role in the development and severity of asthma, say the authors.

The disease is more common in young women after they have started having periods, while hospital admissions for asthma are more common among women than men.

The severity of asthma also varies throughout the menstrual cycle and during pregnancy, and the incidence of the disease tends to fall after the menopause, except among those who put on a lot of weight, the authors point out.

They conclude that while their findings point to an increased risk of asthma, this must be judged in "the light of all the other health effects of HRT use, including its beneficial effect on the quality of life of menopausal women."


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Estrogen-only hormone replacement therapy may increase risk of asthma after menopause." ScienceDaily. ScienceDaily, 8 February 2010. <www.sciencedaily.com/releases/2010/02/100207214122.htm>.
BMJ-British Medical Journal. (2010, February 8). Estrogen-only hormone replacement therapy may increase risk of asthma after menopause. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2010/02/100207214122.htm
BMJ-British Medical Journal. "Estrogen-only hormone replacement therapy may increase risk of asthma after menopause." ScienceDaily. www.sciencedaily.com/releases/2010/02/100207214122.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins