Featured Research

from universities, journals, and other organizations

New approach to treating breast and prostate cancers

Date:
February 9, 2010
Source:
Loyola University Health System
Summary:
In a new approach to developing treatments for breast cancer, prostate cancer and enlarged hearts, researchers are zeroing in on a workhorse protein called RSK. When activated, RSK is involved in cell survival, cell proliferation, cell enlargement and a rare disease called Carney complex.

In a new approach to developing treatments for breast cancer, prostate cancer and enlarged hearts, Loyola University Chicago Stritch School of Medicine researchers are zeroing in on a workhorse protein called RSK.

When activated, RSK is involved in cell survival, cell proliferation and cell enlargement. These properties contribute towards cancer progression, heart enlargement and tumors associated with a genetic disease called Carney complex. Loyola researchers have discovered that a regulatory protein binds to RSK. This regulatory protein effectively keeps RSK's activity in check.

In a study to be published in the Journal of Biological Chemistry, Patel and colleagues located the specific region of the regulatory protein that binds to RSK. The study was published online Jan. 4 in advance of print publication.

"The implications are widespread, and will also change textbooks for students," said Tarun Patel, PhD, chairman of the Department of Molecular Pharmacology & Therapeutics at Loyola University Chicago Stritch School of Medicine.

It was previously known that the regulatory protein that binds RSK is also associated with another enzyme known as PKA. PKA is critical in maintaining normal body functions including heart rate, contraction of the heart, blood pressure, hormone release, learning and memory. PKA also is involved in modulating tumor growth and progression. Because RSK and PKA compete for binding with the same regulatory protein, they end up modulating each other's activities.

These fundamental findings could point toward new approaches to developing drugs to keep RSK or PKA in check. Such drugs would, in effect, do the job of the regulatory protein. This could prove useful in treating conditions in which RSK is activated, such as breast and prostate cancer and heart enlargement.

Patel said this discovery is also of great importance for patients with Carney complex. Carney complex is an inherited disease that includes such symptoms as spotty skin pigmentation, benign or cancerous tumors of hormone-producing glands, and unusual benign tumors in the heart that can cause fatal heart attacks. Approximately 500 cases have been reported in the United States.

It's been known for years that Carney complex is associated with mutations that cause a deficiency of the regulatory protein that the Patel lab discovered binds to RSK. This would lead to activation of RSK in Carney complex patients and contribute to tumor growth. Currently there are no drugs to specifically treat Carney complex. Therefore, developing medications to inactivate RSK could prove to be an important new therapeutic approach for Carney complex patients.

Patel is senior author of the study. Other co-authors are Deepti Chaturvedi, PhD and first author Xianlong Gao, PhD.


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Cite This Page:

Loyola University Health System. "New approach to treating breast and prostate cancers." ScienceDaily. ScienceDaily, 9 February 2010. <www.sciencedaily.com/releases/2010/02/100209091846.htm>.
Loyola University Health System. (2010, February 9). New approach to treating breast and prostate cancers. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2010/02/100209091846.htm
Loyola University Health System. "New approach to treating breast and prostate cancers." ScienceDaily. www.sciencedaily.com/releases/2010/02/100209091846.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins