Featured Research

from universities, journals, and other organizations

Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans

Date:
February 25, 2010
Source:
American Society for Radiation Oncology
Summary:
The maximal standardized uptake value (called SUVmax) measured from FDG PET readings taken from the primary tumor in head and neck squamous cell carcinoma patients before treatment is a strong predictor of disease-specific survival, overall survival and disease-free survival, while pretreatment SUVmax for lymphodenopathy is strongly associated with distant metastasis, according to a new study.

The maximal standardized uptake value (called SUVmax) measured from FDG PET readings taken from the primary tumor in head and neck squamous cell carcinoma patients before treatment is a strong predictor of disease-specific survival, overall survival and disease-free survival, while pretreatment SUVmax for lymphodenopathy is strongly associated with distant metastasis, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM.

Since the head and neck area of the body is very rich in lymphatic drainage, it is common for head and neck cancer patients to also have lympahdenopathy, which is an enlarged neck lymph node. Researchers from the University Hospitals Case Medical Center in Cleveland and the University of Nevada at Reno School of Public health in Reno, Nev., conducted a retrospective study of 295 patients treated with IMRT, with 177 having FDG PET before treatment and having a record of SUVmax for either their primary tumor and/or lymphadenopathy (SUV-LN).

"The findings of this study show that we may use SUV before treatment to personalize treatment approaches for some head and neck cancer patients since SUV has been shown to be associated with treatment outcomes," Min Yao, M.D., Ph.D., lead author of the study and a radiation oncologist at University Hospitals Case Medical Center in Cleveland, said. "Higher SUV may mean more aggressive treatment approaches, and since we now know that SUV of the lymph node is associated with distant metastasis, those patients with high SUV-LN may need more aggressive systemic chemotherapy."

The three-year distant metastasis-free survival and disease specific survival rates for all patients were both 78.8 percent and the disease free survival and overall survival rates were 63.95 and 67.4 percent, respectively. SUVmax of the primary tumor was found to be significantly associated with disease specific survival and overall survival and strongly associated with disease free survival. SUV-LN was significantly associated with distant metastasis, with the distant metastasis-free survival rate being 82.1 percent at three years when the SUV-LN was less than 11.3 and 63.4 percent when the SUV-LN was greater than 11.3.

The abstract, "The Prognostic Significance of Pre-treatment SUV in Head and Neck Squamous Cell Carcinoma Treated with IMRT," will be presented in the plenary session on February 26, 2010.


Story Source:

The above story is based on materials provided by American Society for Radiation Oncology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Radiation Oncology. "Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans." ScienceDaily. ScienceDaily, 25 February 2010. <www.sciencedaily.com/releases/2010/02/100225140900.htm>.
American Society for Radiation Oncology. (2010, February 25). Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2010/02/100225140900.htm
American Society for Radiation Oncology. "Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans." ScienceDaily. www.sciencedaily.com/releases/2010/02/100225140900.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins