Featured Research

from universities, journals, and other organizations

Possible new drug target for head and neck cancers

Date:
March 15, 2010
Source:
Journal of Clinical Investigation
Summary:
Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer; it is the name given to a group of cancers that includes cancer of the mouth. While the prognosis for all patients with HNSCC is not good, it is substantially worse for those whose cancer has already spread (metastasized) to their lymph nodes by the time they are diagnosed. Identifying the molecules involved in promoting metastasis therefore provides potential new targets for drugs that might prevent the spread of cancer to new sites.

Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer; it is the name given to a group of cancers that includes cancer of the mouth. While the prognosis for all patients with HNSCC is not good, it is substantially worse for those whose cancer has already spread (metastasized) to their lymph nodes by the time they are diagnosed. Identifying the molecules involved in promoting metastasis therefore provides potential new targets for drugs that might prevent the spread of cancer to new sites.

A team of researchers, led by Sumin Kang and Jing Chen, at the Winship Cancer Institute of Emory University, Atlanta, has now generated several lines of evidence that suggest that the protein RSK2 might be a potential target for such drugs.

In the study, two of the key lines of evidence highlighting the potential of RSK2 as a therapeutic target were the observations that expression of RSK2 correlated with metastatic progression in patients with HNSCC and that decreasing RSK2 expression substantially reduced the metastatic potential of HNSCC cells in a xenograft mouse model of HNSCC. The authors therefore conclude that RSK2 is involved in the programming of HSNCC cells to become metastatic and that this makes it an ideal target for drugs that might prevent the spread of cancer to new sites.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sumin Kang and Jing Chen et al. p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. Journal of Clinical Investigation, March 15, 2010

Cite This Page:

Journal of Clinical Investigation. "Possible new drug target for head and neck cancers." ScienceDaily. ScienceDaily, 15 March 2010. <www.sciencedaily.com/releases/2010/03/100315172207.htm>.
Journal of Clinical Investigation. (2010, March 15). Possible new drug target for head and neck cancers. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2010/03/100315172207.htm
Journal of Clinical Investigation. "Possible new drug target for head and neck cancers." ScienceDaily. www.sciencedaily.com/releases/2010/03/100315172207.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins