Featured Research

from universities, journals, and other organizations

Perioperative chemoradiotherapy in esophageal squamous cell carcinoma

Date:
April 9, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from China performed a randomized controlled study to evaluate the outcome of preoperative and postoperative chemoradiotherapy (CRT) in patients with local advanced thoracic esophageal squamous cell carcinoma (ESCC). The authors concluded that rational application of preoperative or postoperative CRT can provide a benefit in progression-free survival and overall survival in patients with locally advanced ESCC.

Esophagectomy is a standard treatment for resectable esophageal carcinoma but relatively few patients are cured. Combined neoadjuvant chemoradiotherapy (CRT) or adjuvant CRT with surgery may improve survival but there is concern about treatment morbidity and the best sequencing of CRT and surgery.

A research team from China used a prospective study, based on randomized controlled trial design, to compare preoperative and postoperative CRT to surgery alone in patients with resectable esophageal squamous cell carcinoma (ESCC). Their study will be published on April 7, 2010 in the World Journal of Gastroenterology.

With median follow-up of 45 mo for all the enrolled patients, significant differences in the 1-, 3-, 5-, 10-year overall survival (OS) and progression-free survival (PFS) were detected among the the preoperative CRT, postoperative CRT and surgery groups, respectively. There were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm. For the patients who had radical resection, significant differences in median PFS and median OS were detected among the 3 arms, but there were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm. The local recurrence rates in the preoperative CRT, postoperative CRT group and S group were 11.3%, 14.1% and 35%, respectively. No significant differences were detected among the 3 groups when comparing complications but tended to be in favor of the postoperative CRT and S groups. Toxicities of CRT in the preoperative or postoperative CRT arms were mostly moderate, and could be quickly alleviated by adequate therapy.

Their results illustrated that long-term survival is maximized by the use of CRT followed by surgery for locally advanced esophageal cancer. However, patients are more likely to develop toxicity. As therapies improve, it is likely that the toxicity may be reduced and neoadjuvant CRT may provide a more marked benefit in esophageal cancer. Meanwhile, postoperative CRT can also be safely administered and considered as the multimodal treatment of choice for locally advanced ESCC.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lv J, Cao XF, Zhu B, Ji L, Tao L, Wang DD. Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma. World Journal of Gastroenterology, 2010; 16 (13): 1649 DOI: 10.3748/wjg.v16.i13.1649

Cite This Page:

World Journal of Gastroenterology. "Perioperative chemoradiotherapy in esophageal squamous cell carcinoma." ScienceDaily. ScienceDaily, 9 April 2010. <www.sciencedaily.com/releases/2010/04/100409093217.htm>.
World Journal of Gastroenterology. (2010, April 9). Perioperative chemoradiotherapy in esophageal squamous cell carcinoma. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/04/100409093217.htm
World Journal of Gastroenterology. "Perioperative chemoradiotherapy in esophageal squamous cell carcinoma." ScienceDaily. www.sciencedaily.com/releases/2010/04/100409093217.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins