Featured Research

from universities, journals, and other organizations

Breast cancer risk tied to grandmother's diet

Date:
April 20, 2010
Source:
Georgetown University Medical Center
Summary:
Eating too much fat in pregnancy may be an indulgence that has a less-than-beneficial effect on generations to come, say researchers. Their unique study in rats shows that pregnant females that ate a high fat diet not only increased breast cancer risk in their female daughters but also in that daughter's offspring -- the "granddaughters."

Eating too much fat in pregnancy may be an indulgence that has a less-than-beneficial effect on generations to come, say researchers at Georgetown Lombardi Comprehensive Cancer Center. Their unique study in rats shows that pregnant females that ate a high fat diet not only increased breast cancer risk in their female daughters but also in that daughter's offspring -- the "granddaughters."

Details of the study were presented at the AACR 101st Annual Meeting 2010.

The researchers say they don't know why this risk is passed on through two generations, but they believe it occurs through as-yet unknown "epigenetic" changes that result in an increase in terminal end buds in the breast tissue -- an increase that apparently can then be passed on through generations. These buds are believed to be the structures where breast cancer can develop, and having more of these structures seems to increase breast cancer risk, says the study's lead investigator, Sonia de Assis, Ph.D., a postdoctoral fellow in Leena Hilakivi-Clarke's laboratory at Lombardi. "That is our theory, but we really don't know how it is happening -- just yet."

The researchers add that while the grandmother ate a diet that was 43 percent fat, she didn't eat more calories than a control population of rats, and both her daughters and granddaughters ate a normal chow.

The researchers also found that the risk appears to not only extend from mother to daughter and granddaughter, but also from mother to son to granddaughter. For example, the daughters of male and female rats born from mother rats that ate a lot of fat had an 80 percent chance of developing breast cancer, but the risk was about 69 percent if the granddaughter's mother or father was born from a rat that ate normally and the other parent came from a high-fat-consuming parent. By contrast, granddaughters of grandmother rats who ate a normal chow had a 50 percent chance of developing breast cancer.

They also studied a different control populations of rats given estradiol- a form of estrogen -- and saw no increase in breast cancer risk in granddaughters. That suggests that the increased estrogen production related to eating more fat is not the source of the problem, they say.

"The implications from this study are that pregnant mothers need to eat a well balanced diet because they may be affecting the future health of their daughters and granddaughters," says de Assis.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Breast cancer risk tied to grandmother's diet." ScienceDaily. ScienceDaily, 20 April 2010. <www.sciencedaily.com/releases/2010/04/100419172840.htm>.
Georgetown University Medical Center. (2010, April 20). Breast cancer risk tied to grandmother's diet. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2010/04/100419172840.htm
Georgetown University Medical Center. "Breast cancer risk tied to grandmother's diet." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419172840.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins