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Nephrology: New insight into common kidney disease

Date:
April 26, 2010
Source:
Journal of Clinical Investigation
Summary:
The kidney disease crescentic glomerulonephritis rapidly progresses to acute kidney failure and death within months if it is not treated. Even with treatment, many patients progress to end-stage kidney disease and require dialysis and sometimes a kidney transplant. New research in mice has identified a potential new drug target for the treatment of crescentic glomerulonephritis.

The kidney disease crescentic glomerulonephritis rapidly progresses to acute kidney failure and death within months if it is not treated. Even with treatment, many patients progress to end-stage kidney disease and require dialysis and sometimes a kidney transplant.

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New research in mice, performed by Alan Salama and colleagues, at Hammersmith Hospital, United Kingdom, has identified a potential new drug target for the treatment of crescentic glomerulonephritis.

In the study, mice lacking the mannose receptor protein were found to be protected from crescentic glomerulonephritis. This protection was associated with decreased kidney damage mediated by cells known as macrophages and mesangial cells. Further, macrophages lacking the mannose receptor actually became antiinflammatory in the kidney after they interacted with mesangial cells.

The authors therefore suggest that targeting the mannose receptor might provide a new approach to treating crescentic glomerulonephritis. Importantly, this approach would not have the wide-ranging immunosuppressive effects that many current therapies have.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Konstantia-Maria Chavele, Luisa Martinez-Pomares, Jan Domin, Samantha Pemberton, Stuart M. Haslam, Anne Dell, H. Terence Cook, Charles D. Pusey, Siamon Gordon and Alan D. Salama. Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI41560

Cite This Page:

Journal of Clinical Investigation. "Nephrology: New insight into common kidney disease." ScienceDaily. ScienceDaily, 26 April 2010. <www.sciencedaily.com/releases/2010/04/100419233256.htm>.
Journal of Clinical Investigation. (2010, April 26). Nephrology: New insight into common kidney disease. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/04/100419233256.htm
Journal of Clinical Investigation. "Nephrology: New insight into common kidney disease." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419233256.htm (accessed November 28, 2014).

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