Featured Research

from universities, journals, and other organizations

Bone-marrow stem cells in multiple sclerosis show promise

Date:
May 5, 2010
Source:
University of Bristol
Summary:
A groundbreaking trial to test bone-marrow stem cell therapy with a small group of patients with multiple sclerosis has been shown to have possible benefits for the treatment of the disease.

A groundbreaking trial to test bone marrow stem cell therapy with a small group of patients with multiple sclerosis (MS) has been shown to have possible benefits for the treatment of the disease.

Related Articles


Bone marrow stem cells have been shown in several experimental studies to have beneficial effects in disease models of MS. The research team, led by Neil Scolding, Burden Professor of Clinical Neurosciences for the University of Bristol and North Bristol NHS Trust, have now completed a small trial in patients with MS to begin translating these findings from the laboratory to the clinic.

The Bristol team report on this pioneering trial in an article published online in Clinical Pharmacology and Therapeutics. The study was performed at the Institute of Clinical Neurosciences, Frenchay Hospital, Bristol and the Bristol Haematology and Oncology Centre.

The study explored the safety and feasibility of cell therapy in patients with MS. Participants had a general anaesthetic during which bone marrow was harvested. The marrow cells were filtered and prepared so that they could be injected into the patient's vein later the same day.

The procedure was well tolerated and the participants were followed up for a year. No serious adverse effects were encountered. The results of clinical scores were consistent with stable disease. The results of neurophysiological tests raised the possibility of benefit.

Professor Neil Scolding said: "We are encouraged by the results of this early study. The safety data are reassuring and the suggestion of benefit tantalising. A larger study is required to assess the effectiveness of bone marrow cellular therapy in treating MS. We are hopeful that recruitment to this phase 2/3 study may begin towards the end of this year.

"Research into the underlying mechanisms is ongoing and vital, in order to build on these results. We believe that stem cells mobilised from the marrow to the blood are responsible, and that they help improve disease in several ways, including neuroprotection and immune modulation."

The aim of the trial was to find out what effects, good or bad, bone marrow stem cells has on patients with MS, and their disability.

Bone marrow is known to contain stem cells capable of replacing cells in many types of tissues and organs -- and so is of great interest to those working to develop new treatments for many diseases, including those affecting the nervous system.

The study has been funded by the Adrian Wright Bequest, The Patrick Berthoud Charitable Trust, the Silverman Family Foundation, The Myelin Project, the Captain SK Trust and The Burden Trust.


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. C M Rice, E A Mallam, A L Whone, P Walsh, D J Brooks, N Kane, S R Butler, D I Marks and N J Scolding. Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis. Clinical Pharmacology and Therapeutics, May 5, 2010 DOI: 10.1038/clpt.2010.44

Cite This Page:

University of Bristol. "Bone-marrow stem cells in multiple sclerosis show promise." ScienceDaily. ScienceDaily, 5 May 2010. <www.sciencedaily.com/releases/2010/05/100505113237.htm>.
University of Bristol. (2010, May 5). Bone-marrow stem cells in multiple sclerosis show promise. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2010/05/100505113237.htm
University of Bristol. "Bone-marrow stem cells in multiple sclerosis show promise." ScienceDaily. www.sciencedaily.com/releases/2010/05/100505113237.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Ways To Celebrate National Nutrition Month

The Best Ways To Celebrate National Nutrition Month

Buzz60 (Mar. 2, 2015) Just when your New Year&apos;s Resolution is losing steam, March comes with fresh inspiration. TC Newman (@PurpleTCNewman) has some tips to incorporate into your lifestyle during National Nutrition Month. Video provided by Buzz60
Powered by NewsLook.com
WHO: 1.1 Billion At Risk Of Hearing Loss, Will They Listen?

WHO: 1.1 Billion At Risk Of Hearing Loss, Will They Listen?

Newsy (Mar. 2, 2015) According to the World Health Organization, 1.1 billion young people are at risk of hearing loss. Can this staggering number change things? Video provided by Newsy
Powered by NewsLook.com
Rehab Robot Helps Restore Damaged Muscles and Nerves

Rehab Robot Helps Restore Damaged Muscles and Nerves

Reuters - Innovations Video Online (Mar. 1, 2015) A rehabilitation robot prototype to help restore deteriorated nerves and muscles using electromyography and computer games. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins