Featured Research

from universities, journals, and other organizations

Science closing in on mystery of age-related memory loss, says neurobiologist

Date:
May 11, 2010
Source:
University of Alabama at Birmingham
Summary:
The world's scientific community may be one step closer to understanding age-related memory loss, and to developing a drug that might help boost memory. In a new editorial, a U.S. neurobiologist says that research from the European Neuroscience Institute provides proof of concept that drugs known as histone deacetylase inhibitors have great promise in stopping memory loss -- and even in boosting the formation of memory in animal models.

The world's scientific community may be one step closer to understanding age-related memory loss, and to developing a drug that might help boost memory. In an editorial published May 7 in Science, J. David Sweatt, Ph.D., chair of the University of Alabama at Birmingham (UAB) Department of Neurobiology, says that drugs known as histone deacetylase inhibitors are showing great promise in stopping memory loss -- and even in boosting the formation of memory in animal models.

Related Articles


Sweatt's editorial was published in conjunction with findings published in Science from researchers led by Shahaf Peleg at the European Neuroscience Institute at University Goettingen in Germany. The European researchers' findings supplement and support work done previously in Sweatt's laboratory.

"It's a real proof of concept," said Sweatt. "We've been studying histone deacetylase inhibitors for some 10 years. Studies in our lab and elsewhere strongly suggested that these drugs could potentially reverse aging-associated memory dysfunction.

"The new results from Peleg's group provide important proof-of-principal that this might be a viable approach to therapeutic interventions in aging."

Sweatt, director of the Evelyn F. McKnight Brain Institute at UAB, cautions that the findings have so far only been observed in mouse models. He says further research is warranted to see if the findings translate to memory formation in humans.

He is especially encouraged because histone deacetylase inhibitors seem to be beneficial in both normal age-related memory decline, as evidenced by the Peleg team's findings, and in a mouse model of Alzheimer's disease, as reported by Sweatt's laboratory earlier this year in a different paper in Neuropsychopharmacology.

"These studies will hopefully lead to more effective prevention strategies to improve quality of life in the aged, as well as contribute to a better understanding of memory," Sweatt said.


Story Source:

The above story is based on materials provided by University of Alabama at Birmingham. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. David Sweatt. Epigenetics and Cognitive Aging. Science, 2010; 328 (5979): 701-702 DOI: 10.1126/science.1189968

Cite This Page:

University of Alabama at Birmingham. "Science closing in on mystery of age-related memory loss, says neurobiologist." ScienceDaily. ScienceDaily, 11 May 2010. <www.sciencedaily.com/releases/2010/05/100506141557.htm>.
University of Alabama at Birmingham. (2010, May 11). Science closing in on mystery of age-related memory loss, says neurobiologist. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2010/05/100506141557.htm
University of Alabama at Birmingham. "Science closing in on mystery of age-related memory loss, says neurobiologist." ScienceDaily. www.sciencedaily.com/releases/2010/05/100506141557.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Binge-Watching TV Linked To Loneliness

Binge-Watching TV Linked To Loneliness

Newsy (Jan. 29, 2015) Researchers at University of Texas at Austin found a link between binge-watching TV shows and feelings of loneliness and depression. Video provided by Newsy
Powered by NewsLook.com
Signs You Might Be The Passive Aggressive Friend

Signs You Might Be The Passive Aggressive Friend

BuzzFeed (Jan. 28, 2015) "No, I&apos;m not mad. Why, are you mad?" Video provided by BuzzFeed
Powered by NewsLook.com
City Divided: A Look at Model Schools in the TDSB

City Divided: A Look at Model Schools in the TDSB

The Toronto Star (Jan. 27, 2015) Model schools are rethinking how they engage with the community to help enhance the lives of the students and their parents. Video provided by The Toronto Star
Powered by NewsLook.com
Man Saves Pennies For 65 Years

Man Saves Pennies For 65 Years

Rooftop Comedy (Jan. 26, 2015) A man in Texas saved every penny he found for 65 years, and this week he finally cashed them in. Bank tellers at Prosperity Bank in Slaton, Texas were shocked when Ira Keys arrived at their bank with over 500 pounds of loose pennies stored in coffee cans. After more than an hour of sorting and counting, it turned out the 81 year-old was in possession of 81,600 pennies, or $816. And he&apos;s got more at home! Video provided by Rooftop Comedy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins