Featured Research

from universities, journals, and other organizations

Science closing in on mystery of age-related memory loss, says neurobiologist

Date:
May 11, 2010
Source:
University of Alabama at Birmingham
Summary:
The world's scientific community may be one step closer to understanding age-related memory loss, and to developing a drug that might help boost memory. In a new editorial, a U.S. neurobiologist says that research from the European Neuroscience Institute provides proof of concept that drugs known as histone deacetylase inhibitors have great promise in stopping memory loss -- and even in boosting the formation of memory in animal models.

The world's scientific community may be one step closer to understanding age-related memory loss, and to developing a drug that might help boost memory. In an editorial published May 7 in Science, J. David Sweatt, Ph.D., chair of the University of Alabama at Birmingham (UAB) Department of Neurobiology, says that drugs known as histone deacetylase inhibitors are showing great promise in stopping memory loss -- and even in boosting the formation of memory in animal models.

Sweatt's editorial was published in conjunction with findings published in Science from researchers led by Shahaf Peleg at the European Neuroscience Institute at University Goettingen in Germany. The European researchers' findings supplement and support work done previously in Sweatt's laboratory.

"It's a real proof of concept," said Sweatt. "We've been studying histone deacetylase inhibitors for some 10 years. Studies in our lab and elsewhere strongly suggested that these drugs could potentially reverse aging-associated memory dysfunction.

"The new results from Peleg's group provide important proof-of-principal that this might be a viable approach to therapeutic interventions in aging."

Sweatt, director of the Evelyn F. McKnight Brain Institute at UAB, cautions that the findings have so far only been observed in mouse models. He says further research is warranted to see if the findings translate to memory formation in humans.

He is especially encouraged because histone deacetylase inhibitors seem to be beneficial in both normal age-related memory decline, as evidenced by the Peleg team's findings, and in a mouse model of Alzheimer's disease, as reported by Sweatt's laboratory earlier this year in a different paper in Neuropsychopharmacology.

"These studies will hopefully lead to more effective prevention strategies to improve quality of life in the aged, as well as contribute to a better understanding of memory," Sweatt said.


Story Source:

The above story is based on materials provided by University of Alabama at Birmingham. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. David Sweatt. Epigenetics and Cognitive Aging. Science, 2010; 328 (5979): 701-702 DOI: 10.1126/science.1189968

Cite This Page:

University of Alabama at Birmingham. "Science closing in on mystery of age-related memory loss, says neurobiologist." ScienceDaily. ScienceDaily, 11 May 2010. <www.sciencedaily.com/releases/2010/05/100506141557.htm>.
University of Alabama at Birmingham. (2010, May 11). Science closing in on mystery of age-related memory loss, says neurobiologist. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2010/05/100506141557.htm
University of Alabama at Birmingham. "Science closing in on mystery of age-related memory loss, says neurobiologist." ScienceDaily. www.sciencedaily.com/releases/2010/05/100506141557.htm (accessed August 20, 2014).

Share This




More Mind & Brain News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Newsy (Aug. 19, 2014) A study by King's College London says there's a link between how well kids draw at age 4 and how intelligent they are later in life. Video provided by Newsy
Powered by NewsLook.com
Mental, Neurological Disabilities Up 21% Among Kids

Mental, Neurological Disabilities Up 21% Among Kids

Newsy (Aug. 18, 2014) New numbers show a decade's worth of changes in the number of kids with disabilities. They suggest mental disabilities are up; physical ones are down. Video provided by Newsy
Powered by NewsLook.com
Fake Weed Wreaks Havoc In New Hampshire

Fake Weed Wreaks Havoc In New Hampshire

Newsy (Aug. 17, 2014) New Hampshire's governor declared a state of emergency after more than 40 overdoses of synthetic marijuana in one week throughout the state. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins