Featured Research

from universities, journals, and other organizations

Model demonstrates infectious cause of asthma

Date:
May 25, 2010
Source:
American Society for Microbiology
Summary:
Scientists have developed an animal model that shows how an early childhood lung infection can cause asthma later in life.

Scientists from the University of Massachusetts have developed an animal model that shows how an early childhood lung infection can cause asthma later in life.

They are presenting their data at the 110th General Meeting of the American Society for Microbiology in San Diego.

Asthma is the most common chronic respiratory disease affecting young children all over the world and the number of new pediatric asthma cases has dramatically increased over the last 20 years. Chlamydia infection of the respiratory tract has been identified as a risk factor in asthma development.

"Even with this knowledge, we currently do not understand how this pathogen causes asthma symptoms and if it really initiates the disease," says Katir Patel, one of the researchers on the study. "In our mouse model we are able to demonstrate that when mice are infected very early in life with respiratory chlamydia, asthma was induced."

The key appears to be an altered immune response in neonatal mice. Patel and colleagues began the study by inducing chlamydial lung infection in newborn neonatal as well as in adult mice and compared the immune response and outcomes. The immune response in the newborns was significantly different from adults and the newborns never cleared the infection, while the adults did.

"When allergic airway disease was induced in this mouse model, infected neonatal mice significantly increased their production of allergic type chemical messengers characteristic of asthma, compared to uninfected neonatal controls and infected adult groups," says Patel.

"Our data indicate that early-life infections with chlamydia may drive aberrant immune responses ultimately causing chronic infection and inducing asthma disease," says Patel. "Early life respiratory colonization with chlamydia elicits pathogen-specific IgE antibody production, which for the first time provides evidence of an infectious asthma phenotype."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Model demonstrates infectious cause of asthma." ScienceDaily. ScienceDaily, 25 May 2010. <www.sciencedaily.com/releases/2010/05/100524161240.htm>.
American Society for Microbiology. (2010, May 25). Model demonstrates infectious cause of asthma. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2010/05/100524161240.htm
American Society for Microbiology. "Model demonstrates infectious cause of asthma." ScienceDaily. www.sciencedaily.com/releases/2010/05/100524161240.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins