Featured Research

from universities, journals, and other organizations

Model demonstrates infectious cause of asthma

Date:
May 25, 2010
Source:
American Society for Microbiology
Summary:
Scientists have developed an animal model that shows how an early childhood lung infection can cause asthma later in life.

Scientists from the University of Massachusetts have developed an animal model that shows how an early childhood lung infection can cause asthma later in life.

They are presenting their data at the 110th General Meeting of the American Society for Microbiology in San Diego.

Asthma is the most common chronic respiratory disease affecting young children all over the world and the number of new pediatric asthma cases has dramatically increased over the last 20 years. Chlamydia infection of the respiratory tract has been identified as a risk factor in asthma development.

"Even with this knowledge, we currently do not understand how this pathogen causes asthma symptoms and if it really initiates the disease," says Katir Patel, one of the researchers on the study. "In our mouse model we are able to demonstrate that when mice are infected very early in life with respiratory chlamydia, asthma was induced."

The key appears to be an altered immune response in neonatal mice. Patel and colleagues began the study by inducing chlamydial lung infection in newborn neonatal as well as in adult mice and compared the immune response and outcomes. The immune response in the newborns was significantly different from adults and the newborns never cleared the infection, while the adults did.

"When allergic airway disease was induced in this mouse model, infected neonatal mice significantly increased their production of allergic type chemical messengers characteristic of asthma, compared to uninfected neonatal controls and infected adult groups," says Patel.

"Our data indicate that early-life infections with chlamydia may drive aberrant immune responses ultimately causing chronic infection and inducing asthma disease," says Patel. "Early life respiratory colonization with chlamydia elicits pathogen-specific IgE antibody production, which for the first time provides evidence of an infectious asthma phenotype."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Model demonstrates infectious cause of asthma." ScienceDaily. ScienceDaily, 25 May 2010. <www.sciencedaily.com/releases/2010/05/100524161240.htm>.
American Society for Microbiology. (2010, May 25). Model demonstrates infectious cause of asthma. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/05/100524161240.htm
American Society for Microbiology. "Model demonstrates infectious cause of asthma." ScienceDaily. www.sciencedaily.com/releases/2010/05/100524161240.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins