Featured Research

from universities, journals, and other organizations

Predicting severity of breast cancer

Date:
May 31, 2010
Source:
Royal College of Surgeons in Ireland (RCSI)
Summary:
Researchers have identified a biomarker in patient blood which can predict the severity of breast cancer in patients and may enable clinicians to track patients throughout the course of their treatment.

Researchers from the Royal College of Surgeons in Ireland (RCSI) have identified a biomarker in patient blood which can predict the severity of breast cancer in patients and may enable clinicians to track patients throughout the course of their treatment.

Around 75 percent of breast cancers are fuelled by the hormone estrogen which encourages them to grow. Although this type of breast cancer can be treated with drugs such as tamoxifen, many people develop resistance and see their breast cancer return.

The study published in Cancer Research reports on the identification of biomarkers which may help distinguish breast cancer patients with a greater risk of disease recurrence. This may lead to the development of personalised treatment programmes for individual patients.

The research, funded by Science Foundation Ireland (SFI) and Breast Cancer Ireland (BCI) investigated the protein changes in breast cancer that is resistant to treatment and found a higher level of a protein called HOXC11 and the presence of a secreted molecule S100-beta that is detected via a simple blood test.

Lead researcher, Dr Leonie Young, Leader of Surgical Research in RCSI said "We hope this research will provide vital information about drug resistance to ensure that people with breast cancer are getting treatments that will benefit them."

Further work on this project is being funded by the UK based charity Breast Cancer Campaign and will provide vital information so that a new blood test can be designed to predict which breast cancers will become drug resistant to current therapies ensuring that only those who will benefit from a particular treatment actually receive it.

Breast cancer is the second most common cancer in Ireland after non-melanomatous skin cancer. Breast cancer accounts for 28% of all cancers in women in Ireland, with an average of 1726 new diagnosis each year. Though management has improved over the years, breast cancer continues to be responsible for an average of 644 Irish female deaths each year. It is the leading cause of cancer related deaths in women in Ireland, with mortality 33% higher in Ireland than in the USA.


Story Source:

The above story is based on materials provided by Royal College of Surgeons in Ireland (RCSI). Note: Materials may be edited for content and length.


Journal Reference:

  1. M. McIlroy, D. McCartan, S. Early, P. O Gaora, S. Pennington, A. D.K. Hill, L. S. Young. Interaction of Developmental Transcription Factor HOXC11 with Steroid Receptor Coactivator SRC-1 Mediates Resistance to Endocrine Therapy in Breast Cancer. Cancer Research, 2010; 70 (4): 1585 DOI: 10.1158/0008-5472.CAN-09-3713

Cite This Page:

Royal College of Surgeons in Ireland (RCSI). "Predicting severity of breast cancer." ScienceDaily. ScienceDaily, 31 May 2010. <www.sciencedaily.com/releases/2010/05/100525103709.htm>.
Royal College of Surgeons in Ireland (RCSI). (2010, May 31). Predicting severity of breast cancer. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/05/100525103709.htm
Royal College of Surgeons in Ireland (RCSI). "Predicting severity of breast cancer." ScienceDaily. www.sciencedaily.com/releases/2010/05/100525103709.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins