Featured Research

from universities, journals, and other organizations

Blood flows differently through the brains of schizophrenic patients

Date:
June 4, 2010
Source:
Radiological Society of North America
Summary:
Researchers in Germany have used a magnetic resonance imaging technique called continuous arterial spin labeling to map cerebral blood flow patterns in schizophrenic patients quickly and without using radiation or contrast agents.

Researchers in Germany have used a magnetic resonance imaging (MRI) technique called continuous arterial spin labeling (CASL) to map cerebral blood flow patterns in schizophrenic patients quickly and without using radiation or contrast agents.

Their findings appear in the online edition and July printed issue of the journal Radiology.

"Arterial spin labeling is a powerful technique that can help reduce the cost and complexity of examinations," said the study's lead author, Lukas Scheef, M.D., from the Department of Radiology at University of Bonn, Germany. "It can also be more readily repeated than methods that involve the use of contrast agents and radiotracers."

Schizophrenia is a chronic and severe brain disorder that affects approximately 2.4 million American adults, according to the National Institute of Mental Health. Symptoms can include hallucinations, delusions, disordered thinking, movement disorders, social withdrawal and cognitive deficits.

In the study, conducted at the University Hospital of Bonn in Germany, researchers used CASL MRI to compare cerebral blood flow in 11 non-medicated patients with schizophrenia and 25 healthy controls. The patient group included three women with a mean age of 36 years and eight men with a mean age of 32 years. The control group included 13 women (mean age, 29 years) and 12 men (mean age, 30 years).

The results revealed that compared to the healthy controls, the schizophrenic patients had extensive areas of hypoperfusion, or lower blood flow than normal in the frontal lobes and frontal cortex, anterior and medial cingulate gyri, and parietal lobes. These regions are associated with a number of higher cognitive functions including planning, decision making, judgment and impulse control.

Hyperperfusion, or increased blood flow, was observed in the cerebellum, brainstem and thalamus of the schizophrenic patients.

"Our CASL study revealed patterns of hypo- and hyperperfusion similar to the perfusion patterns observed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies of schizophrenic patients," Dr. Scheef said.

Unlike PET and SPECT studies, CASL MR images can be quickly acquired without the use of ionizing radiation or contrast agents. In CASL MRI, arterial blood water is magnetically labeled in order to non-invasively measure cerebral blood flow.

"CASL MRI may allow researchers to gain a better understanding of schizophrenia," Dr. Scheef said. "In the long run, it may help to individualize and optimize treatment."


Story Source:

The above story is based on materials provided by Radiological Society of North America. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Scheef, C. Manka, M. Daamen, K. U. Kuhn, W. Maier, H. H. Schild, F. Jessen. Resting-State Perfusion in Nonmedicated Schizophrenic Patients: A Continuous Arterial Spin-labeling 3.0-T MR Study. Radiology, 2010; DOI: 10.1148/radiol.10091224

Cite This Page:

Radiological Society of North America. "Blood flows differently through the brains of schizophrenic patients." ScienceDaily. ScienceDaily, 4 June 2010. <www.sciencedaily.com/releases/2010/05/100526091040.htm>.
Radiological Society of North America. (2010, June 4). Blood flows differently through the brains of schizophrenic patients. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2010/05/100526091040.htm
Radiological Society of North America. "Blood flows differently through the brains of schizophrenic patients." ScienceDaily. www.sciencedaily.com/releases/2010/05/100526091040.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins