Featured Research

from universities, journals, and other organizations

Blood flows differently through the brains of schizophrenic patients

Date:
June 4, 2010
Source:
Radiological Society of North America
Summary:
Researchers in Germany have used a magnetic resonance imaging technique called continuous arterial spin labeling to map cerebral blood flow patterns in schizophrenic patients quickly and without using radiation or contrast agents.

Researchers in Germany have used a magnetic resonance imaging (MRI) technique called continuous arterial spin labeling (CASL) to map cerebral blood flow patterns in schizophrenic patients quickly and without using radiation or contrast agents.

Their findings appear in the online edition and July printed issue of the journal Radiology.

"Arterial spin labeling is a powerful technique that can help reduce the cost and complexity of examinations," said the study's lead author, Lukas Scheef, M.D., from the Department of Radiology at University of Bonn, Germany. "It can also be more readily repeated than methods that involve the use of contrast agents and radiotracers."

Schizophrenia is a chronic and severe brain disorder that affects approximately 2.4 million American adults, according to the National Institute of Mental Health. Symptoms can include hallucinations, delusions, disordered thinking, movement disorders, social withdrawal and cognitive deficits.

In the study, conducted at the University Hospital of Bonn in Germany, researchers used CASL MRI to compare cerebral blood flow in 11 non-medicated patients with schizophrenia and 25 healthy controls. The patient group included three women with a mean age of 36 years and eight men with a mean age of 32 years. The control group included 13 women (mean age, 29 years) and 12 men (mean age, 30 years).

The results revealed that compared to the healthy controls, the schizophrenic patients had extensive areas of hypoperfusion, or lower blood flow than normal in the frontal lobes and frontal cortex, anterior and medial cingulate gyri, and parietal lobes. These regions are associated with a number of higher cognitive functions including planning, decision making, judgment and impulse control.

Hyperperfusion, or increased blood flow, was observed in the cerebellum, brainstem and thalamus of the schizophrenic patients.

"Our CASL study revealed patterns of hypo- and hyperperfusion similar to the perfusion patterns observed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies of schizophrenic patients," Dr. Scheef said.

Unlike PET and SPECT studies, CASL MR images can be quickly acquired without the use of ionizing radiation or contrast agents. In CASL MRI, arterial blood water is magnetically labeled in order to non-invasively measure cerebral blood flow.

"CASL MRI may allow researchers to gain a better understanding of schizophrenia," Dr. Scheef said. "In the long run, it may help to individualize and optimize treatment."


Story Source:

The above story is based on materials provided by Radiological Society of North America. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Scheef, C. Manka, M. Daamen, K. U. Kuhn, W. Maier, H. H. Schild, F. Jessen. Resting-State Perfusion in Nonmedicated Schizophrenic Patients: A Continuous Arterial Spin-labeling 3.0-T MR Study. Radiology, 2010; DOI: 10.1148/radiol.10091224

Cite This Page:

Radiological Society of North America. "Blood flows differently through the brains of schizophrenic patients." ScienceDaily. ScienceDaily, 4 June 2010. <www.sciencedaily.com/releases/2010/05/100526091040.htm>.
Radiological Society of North America. (2010, June 4). Blood flows differently through the brains of schizophrenic patients. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2010/05/100526091040.htm
Radiological Society of North America. "Blood flows differently through the brains of schizophrenic patients." ScienceDaily. www.sciencedaily.com/releases/2010/05/100526091040.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins