Featured Research

from universities, journals, and other organizations

Potential drug target has key role in the heart

Date:
June 1, 2010
Source:
Journal of Clinical Investigation
Summary:
Inhibitors of GSK-3 proteins are being developed as potential therapeutics for numerous conditions, including bipolar disorder, Alzheimer's disease, and diabetes. However, new research in mice indicates that these drugs might have adverse effects on the heart, suggesting that the risk/benefit assessment of such drugs might need to be considered carefully.

Inhibitors of GSK-3 proteins are being developed as potential therapeutics for numerous conditions, including bipolar disorder, Alzheimer disease, and diabetes. However, a team of researchers, led by Thomas Force, at Thomas Jefferson University, Philadelphia, has generated data in mice that indicate that these drugs might have adverse effects on the heart, suggesting that the risk/benefit assessment of such drugs might need to be considered carefully.

In the study, mice lacking GSK-3-alpha were found to develop heart defects when they were analyzed at over 2 months of age. In particular, they had enlarged heart muscle cells and hearts, and their hearts showed an inability to contract optimally. Further, in a model of high blood pressure, which puts substantial stress on the heart, mice lacking GSK-3-alpha developed much more severe heart defects than did normal mice.

These and other data generated in the study lead the authors to conclude that in the absence of GSK-3-alpha, the mouse heart cannot respond effectively to high blood pressure and rapidly fails, raising concern that therapeutic GSK-3 inhibitors might have serious adverse effects.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jibin Zhou, Hind Lal, Xiongwen Chen, Xiying Shang, Jianliang Song, Yingxin Li, Risto Kerkela, Bradley W. Doble, Katrina MacAulay, Morgan DeCaul, Walter J. Koch, John Farber, James Woodgett, Erhe Gao and Thomas Force. GSK-3-alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI41407

Cite This Page:

Journal of Clinical Investigation. "Potential drug target has key role in the heart." ScienceDaily. ScienceDaily, 1 June 2010. <www.sciencedaily.com/releases/2010/06/100601124119.htm>.
Journal of Clinical Investigation. (2010, June 1). Potential drug target has key role in the heart. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2010/06/100601124119.htm
Journal of Clinical Investigation. "Potential drug target has key role in the heart." ScienceDaily. www.sciencedaily.com/releases/2010/06/100601124119.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins