Featured Research

from universities, journals, and other organizations

Possible mechanism identified for how lithium treats bipolar disorder

Date:
June 18, 2010
Source:
Cardiff University
Summary:
Lithium has been established for more than 50 years as one of the most effective treatments for manic depression, clinically termed bipolar disorder. However, scientists have never been entirely sure exactly why it is beneficial. Now, new research suggests a possible mechanism for why lithium works, opening the door for better understanding of the illness and potentially more effective treatments.

Lithium has been established for more than 50 years as one of the most effective treatments for manic depression, clinically termed bipolar disorder.

Related Articles


However, scientists have never been entirely sure exactly why it is beneficial.

Now, new research from Cardiff University scientists suggests a possible mechanism for why Lithium works, opening the door for better understanding of the illness and potentially more effective treatments.

Laboratory studies with cells have shown that an enzyme known as prolyl oligopeptidase (PO) controls a set of genes that determine sensitivity to lithium. Among these genes is ImpA2, which like PO activity itself, has been associated with differences in some bipolar patients. These results reveal a new mechanistic link that could explain these changes in these patients.

Professor Adrian Harwood of Cardiff School of Biosciences, who led the research, said: "We still cannot say definitively how lithium can help stabilise bipolar disorder. However, our research has uncovered a new cell signalling process with links to bipolar disorder.

"This introduces a new mechanism and more candidate genes whose study could lead to greater understanding of the causes of bipolar disorder, better diagnostic tests and new types of drugs that are more effective and have fewer side effects than Lithium does at present."

The research, funded by the Wellcome Trust, is published in the international journal PLoS ONE.


Story Source:

The above story is based on materials provided by Cardiff University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jason King, Melanie Keim, Regina Teo, Karin E Weening, Mridu Kapur, Karina McQuillan, Jonathan Ryves, Ben Rogers, Emma Dalton, Robin S B Williams, Adrian J Harwood. Genetic Control of Lithium Sensitivity and Regulation of Inositol Biosynthetic Genes. PLoS ONE, 2010; DOI: 10.1371/journal.pone.0011151

Cite This Page:

Cardiff University. "Possible mechanism identified for how lithium treats bipolar disorder." ScienceDaily. ScienceDaily, 18 June 2010. <www.sciencedaily.com/releases/2010/06/100617102410.htm>.
Cardiff University. (2010, June 18). Possible mechanism identified for how lithium treats bipolar disorder. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/06/100617102410.htm
Cardiff University. "Possible mechanism identified for how lithium treats bipolar disorder." ScienceDaily. www.sciencedaily.com/releases/2010/06/100617102410.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Tryptophan Isn't Making You Sleepy On Thanksgiving

Tryptophan Isn't Making You Sleepy On Thanksgiving

Newsy (Nov. 27, 2014) — Tryptophan, a chemical found naturally in turkey meat, gets blamed for sleepiness after Thanksgiving meals. But science points to other culprits. Video provided by Newsy
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins