Featured Research

from universities, journals, and other organizations

Study identifies reasons for higher rate of severe sepsis among black patients

Date:
June 22, 2010
Source:
JAMA and Archives Journals
Summary:
A greater frequency of severe sepsis among black patients is attributable to higher rates of infection and higher risks of organ dysfunction than what white patients experience, according to a new study.

A greater frequency of severe sepsis among black patients is attributable to higher rates of infection and higher risks of organ dysfunction than what white patients experience, according to a study in the June 23/30 issue of JAMA.

Severe sepsis, defined as infection complicated by acute organ dysfunction, affects more than 750,000 U.S. residents each year, with a hospital mortality of 28 percent, and occurs more frequently and leads to more deaths in black patients than in white patients. "However, it is not known whether these disparities occur because of differences in susceptibility to infection or in the risk of developing acute organ dysfunction once infection has occurred. This distinction is important for developing interventions to reduce disparities," the authors write.

Florian B. Mayr, M.D., M.P.H., of the University of Pittsburgh, and colleagues conducted a study to determine the extent to which previously reported racial differences in severe sepsis incidence were due to a higher infection rate or a higher risk of acute organ dysfunction. The study included an analysis of infection-related hospitalizations from the 2005 hospital discharge data of 7 U.S. states and infection-related emergency department visits from the 2003-2007 National Hospital Ambulatory Care Survey. Of 8,661,227 non-childbirth-related discharges, 2,261,857 were associated with an infection, and of these, 381,787 (16.8 percent) had severe sepsis.

The researchers found that black patients had a 67 percent higher severe sepsis hospitalization rate than did white patients (9.4 vs. 5.6 per 1000 population). "The higher severe sepsis rate was explained by both a higher infection rate in black patients (47.3 vs. 34.0 per 1000 population) and a higher risk of developing acute organ dysfunction," the authors write.

Also, infection and severe sepsis mortality rates were 1.5-fold and 1.8-fold higher in black than in white patients.

Analysis indicated that higher hospital infection rates among black patients were not because they were more likely to be admitted with an infection or that black patients were more likely to receive care at hospitals with higher recorded infection rates than white patients. The researchers also found that racial disparities in infection and severe sepsis incidence and mortality rates were largest among younger adults. The proportion of invasive pneumococcal disease occurring in adults less than 65 years of age was 73.9 percent among black patients vs. 44.5 percent among white patients.

"In conclusion, higher severe sepsis rates among black patients are explained by both higher infection-related hospitalization rates and a higher risk of acute organ dysfunction. Reducing these racial disparities will require community-based interventions, such as vaccination, improved management of chronic diseases, and hospital-based interventions targeted especially to hospitals that serve large proportions of black patients. Current guidelines for pneumococcal vaccination, one of the largest and most effective strategies to prevent severe sepsis, do not target up to 25 percent of cases among blacks," the authors write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Florian B. Mayr; Sachin Yende; Walter T. Linde-Zwirble; Octavia M. Peck-Palmer; Amber E. Barnato; Lisa A. Weissfeld; Derek C. Angus. Infection Rate and Acute Organ Dysfunction Risk as Explanations for Racial Differences in Severe Sepsis. JAMA, 2010; 303 (24): 2495-2503 [link]

Cite This Page:

JAMA and Archives Journals. "Study identifies reasons for higher rate of severe sepsis among black patients." ScienceDaily. ScienceDaily, 22 June 2010. <www.sciencedaily.com/releases/2010/06/100622161251.htm>.
JAMA and Archives Journals. (2010, June 22). Study identifies reasons for higher rate of severe sepsis among black patients. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2010/06/100622161251.htm
JAMA and Archives Journals. "Study identifies reasons for higher rate of severe sepsis among black patients." ScienceDaily. www.sciencedaily.com/releases/2010/06/100622161251.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins