Featured Research

from universities, journals, and other organizations

New technology for pharmaceutical drug development

Date:
June 23, 2010
Source:
University of Southampton
Summary:
A new technology platform for testing drugs will simplify the process and bring long-term benefits to the pharmaceutical industry.

A new technology platform for testing drugs will simplify the process and bring long-term benefits to the pharmaceutical industry.

Related Articles


Scientists at the University of Southampton and Birkbeck College, University of London are developing a platform consisting of an array of artificial cell membranes that will enable more efficient testing of potential new drugs.

The Bilayer Platform project, which begins this month, has been awarded 1.2 million from the Engineering and Physical Sciences Research Council to develop a new technology that uses artificial bilayer lipid membranes to evaluate the effectiveness of drugs on ion channels.

Professor Hywel Morgan and Dr Maurits de Planque at the University of Southampton's School of Electronics and Computer Science (ECS) will use the clean room technology in the new Mountbatten Building at the University of Southampton to build this novel platform for parallel on-chip electrophysiology. Each membrane patch will contain different ion channels.

According to Dr de Planque, ion channels play a pivotal role in a wide variety of physiological processes and diseases and are consequently of considerable interest to the pharmaceutical industry. It is for this reason the Southampton group has teamed up with the Birkbeck group, led by Professor Bonnie Ann Wallace, who are international experts in ion channel structure and function.

At the moment, pharmaceutical companies use electrodes to test entire cells, which can be expensive and involves testing a number of ion channels within the cell.

About 60 per cent of drugs work on membrane proteins (of which ion channels are a subclass) and the effectiveness of the drug is gauged by measuring activity in the ion channel as a result of administering the drug.

"By putting the ion channel into an artificial membrane, we only have one type of channel, no living cells and a relatively inexpensive method for testing for several of these types of channels at once," said Dr de Planque.

The project, which will take just over three years, will benefit public and private sector industries, as well as driving new research for the treatment of diseases such as chronic pain, epilepsy, and certain types of heart disease. The new technology platform will have many applications for drug discovery and testing long after the research period ends.


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Cite This Page:

University of Southampton. "New technology for pharmaceutical drug development." ScienceDaily. ScienceDaily, 23 June 2010. <www.sciencedaily.com/releases/2010/06/100623085839.htm>.
University of Southampton. (2010, June 23). New technology for pharmaceutical drug development. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2010/06/100623085839.htm
University of Southampton. "New technology for pharmaceutical drug development." ScienceDaily. www.sciencedaily.com/releases/2010/06/100623085839.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins