Featured Research

from universities, journals, and other organizations

Hyperoxia may slow formation of wrinkles; Excess oxygen lessens impact of UVB radiation, study shows

Date:
July 1, 2010
Source:
American Physiological Society
Summary:
It's no secret that UVB radiation from the sun causes wrinkles. However, a new study indicates that oxygen may help combat the formation of wrinkles by lessening tissue damage done by UVB rays.

It's no secret that UVB radiation from the sun causes wrinkles. However, a Japanese study published in the American Journal of Physiology -- Regulatory, Integrative and Comparative Physiology indicates that oxygen may help combat the formation of wrinkles by lessening tissue damage done by UVB rays.

In the study, mice who were placed in an oxygen chamber after exposure to UVB radiation developed fewer wrinkles and showed fewer signs of tissue damage than mice who were exposed to UVB radiation alone.

UVB and Skin Damage

The readily visible hallmarks of skin damage are wrinkles and a thickening in the outer layer of skin, the epidermis. Together they make skin look and feel leathery.

The "sun-weathered" look is merely evidence of what is happening on a molecular level beneath the skin's surface, however. When skin is repeatedly exposed to UVB radiation, new blood vessels form from existing blood vessels in the skin in a process called cutaneous angiogenesis. Several transcription factors -- proteins that bind to specific DNA sequences -- play a role in angiogenesis, including hypoxia inducible factor (HIF-1) and its subunit HIF-1 α and vascular endothelial growth factor (VEGF).

The Study

In the study, the researchers assigned 24 hairless mice into three groups. The control group, the UVB group, and the UVB+HO group. The control group was not exposed to UVB radiation. Both the UVB and the UVB+HO groups were exposed to UVB radiation by a special fluorescent lamp three times per week for five weeks, but the UVB+HO mice were placed in an oxygen chamber for two hours after each irradiation.

Over the five weeks, the mice in the UVB and UVB+HO groups developed wrinkles, but the wrinkles were more pronounced in the UVB group. Likewise, both the UVB and UVB+HO group experienced increased epidermal thickness, but again, this result was more pronounced in the UVB group.

There were differences between the UVB and UVB+HO groups on a molecular level, as well. The level of HIF-1α increased significantly in the UVB group compared to the control group, whereas there was no significant increase in the UVB+HO group. VEGF levels increased in both the UVB and the UVB+HO groups, but the UVB+HO group experienced a smaller increase. This implies that oxygen and the excess amount of oxygen in body tissue, or hyperoxia, that it provides can lessen skin damage and wrinkling caused by UVB radiation.

A Surprising Result

The study had one surprising result, as well, one involving molecules called matrix metalloproteinases (MMPs). Like HIF-1 α and VEGF, they play a role in angiogenesis. Two MMPs in particular, MMP-2 and MMP-9, are thought to accelerate wrinkling by degrading the outer components of cells. However, in this study, MMP-2 levels tended to decrease with exposure to UVB radiation and MMP-9 levels remained the same, even in mice who did not receive oxygen. According to the researchers, this implies that MMP-2 and MMP-9 are not main factors in wrinkle formation and angiogenesis, at least in the early stages of skin damage caused by UVB radiation.

The implications for humans remain to be seen, and the researchers note that further studies are required. In the meantime, the best way to avoid wrinkles caused by UVB radiation is to wear sunscreen.


Story Source:

The above story is based on materials provided by American Physiological Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Kawada, M. Ohtani, N. Ishii. Increased oxygen tension attenuates acute ultraviolet-B-induced skin angiogenesis and wrinkle formation. AJP: Regulatory, Integrative and Comparative Physiology, 2010; DOI: 10.1152/ajpregu.00199.2010

Cite This Page:

American Physiological Society. "Hyperoxia may slow formation of wrinkles; Excess oxygen lessens impact of UVB radiation, study shows." ScienceDaily. ScienceDaily, 1 July 2010. <www.sciencedaily.com/releases/2010/06/100629122956.htm>.
American Physiological Society. (2010, July 1). Hyperoxia may slow formation of wrinkles; Excess oxygen lessens impact of UVB radiation, study shows. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2010/06/100629122956.htm
American Physiological Society. "Hyperoxia may slow formation of wrinkles; Excess oxygen lessens impact of UVB radiation, study shows." ScienceDaily. www.sciencedaily.com/releases/2010/06/100629122956.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins