Featured Research

from universities, journals, and other organizations

HPV infection linked to increased risk of skin cancer

Date:
July 9, 2010
Source:
BMJ-British Medical Journal
Summary:
HPV infection heightens the risk of developing certain skin cancers and is worsened if people are taking immunosuppression drugs, according to a new study.

HPV infection heightens the risk of developing certain skin cancers and is worsened if people are taking immunosuppression drugs, according to a new study published online in the British Medical Journal.

An international team of researchers found that people with several types of human papillomaviruses (HPVs) were more than one and a half times as likely to develop certain skin cancers compared to people with no HPVs.

The most common skin cancers (basal cell carcinoma and squamous cell carcinoma) are increasing globally and ultraviolet radiation is the main established risk factor.

In addition, HPV infection -- of which there are more than 100 types -- may play a role in their development. Other types of HPVs are known to cause cancers of the cervix, vulva, vagina, anus, and penis.

Research so far has identified increased risks for people with skin HPV types called beta HPVs, particularly among organ transplant recipients and people with epidermodysplasia verruciformis (EV) -- a rare genetic disorder, which leads to warts and malignant skin lesions.

Now researchers, led by Professor Margaret Karagas of the Dartmouth Medical School in the USA, wanted to find more conclusive evidence of a link between beta HPVs and the common skin cancers among the general population.

They studied 2,366 people living in New Hampshire, USA, made up of 663 people with squamous cell carcinoma, 898 people with basal cell carcinoma and 805 healthy controls.

As well as interviewing the study participants, the researchers measured HPV antibodies in blood samples of newly diagnosed and confirmed basal cell and squamous cell carcinoma patients from two periods -- July 1993 to June 1995 and July 1997 to March 2000 and matched population controls.

Results showed that people with squamous cell carcinoma, but not basal cell carcinoma, were far more likely to have each of the beta HPV types compared to people in the control group. The likelihood of having squamous cell carcinoma increased as people were found to have more of the HPV types.

For example, people with squamous cell carcinoma were 1.4 times more likely to have two to three types of HPV, and 1.7 times more likely to have greater than eight types of HPV compared with the control group.

The researchers also found that people who were long term users of immunosuppressant drugs had more than a three-fold risk of squamous cell carcinoma in relation to HPV, but with limited statistical precision.

"Given the widespread and growing occurrence of these malignancies, our results raise the possibility of reducing the health and economic burden of these cancers through prevention or treatment of human papillomavirus infection," conclude the authors.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "HPV infection linked to increased risk of skin cancer." ScienceDaily. ScienceDaily, 9 July 2010. <www.sciencedaily.com/releases/2010/07/100708193448.htm>.
BMJ-British Medical Journal. (2010, July 9). HPV infection linked to increased risk of skin cancer. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/07/100708193448.htm
BMJ-British Medical Journal. "HPV infection linked to increased risk of skin cancer." ScienceDaily. www.sciencedaily.com/releases/2010/07/100708193448.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins