Featured Research

from universities, journals, and other organizations

CD74 serves as a survival receptor on colon epithelial cells

Date:
July 30, 2010
Source:
World Journal of Gastroenterology
Summary:
CD74 is a protein expressed by cells of the immune system. A research group in Israel finds that CD74 is expressed on colon epithelial cells of mice, as well as on a malignant cell line from mouse colon. Stimulation of CD74 leads to a signaling cascade resulting in cell survival. Thus, CD74 is a survival receptor in health and disease.

CD74 is a protein that is expressed in and on cells of the immune system, such as B lymphocytes and antigen presenting cells. This protein is known for its function in facilitating antigen presentation enabling the immune response.

Additionally, Professor Shachar's lab has previously shown that CD74 serves as a survival receptor on cells of the immune system, and that its stimulation by its natural ligand -migration inhibitory factor (MIF)- prevents apoptosis (self destruction) of these cells. It was shown that CD74 is markedly expressed on numerous tumors -- hematologic as well as epithelial, and can serve as a prognostic marker. CD74's expression and function on colon intestinal epithelial cells is controversial.

A research article to be published on July 14, 2010 in the World Journal of Gastroenterology addresses this question.

A team of scientists headed by Professor Idit Shachar from the Weizmann Institute of Science in Israel, has demonstrated that CD74 is expressed on colon epithelial cells. CD74 expression on these cells was shown to increase colon epithelial cells survival upon stimulation by its natural ligand MIF.

These findings were further supported by their demonstration in the mouse colorectal cancer cell line, CT-26. Stimulation of CD74 expressed on these cells led to Akt phophorylation and Bcl-2 expression resulting in elevation of cell survival.These findings may open a new target in the research of colorectal cancer.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maharshak N, Cohen S, Lantner F, Hart G, Leng L, Bucala R, Shachar I. CD74 is a survival receptor on colon epithelial cells. World Journal of Gastroenterology, 2010; 16 (26): 3258 DOI: 10.3748/wjg.v16.i26.3258

Cite This Page:

World Journal of Gastroenterology. "CD74 serves as a survival receptor on colon epithelial cells." ScienceDaily. ScienceDaily, 30 July 2010. <www.sciencedaily.com/releases/2010/07/100730091005.htm>.
World Journal of Gastroenterology. (2010, July 30). CD74 serves as a survival receptor on colon epithelial cells. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/07/100730091005.htm
World Journal of Gastroenterology. "CD74 serves as a survival receptor on colon epithelial cells." ScienceDaily. www.sciencedaily.com/releases/2010/07/100730091005.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins