Featured Research

from universities, journals, and other organizations

High malaria transmission areas remain a problem for elimination

Date:
August 12, 2010
Source:
Public Library of Science
Summary:
Current tools for combating malaria, such as artemisinin-combination therapy and increasing coverage of long-lasting insecticide bednets can result in major reductions in Plasmodium falciparum malaria transmission and the associated disease burden in Africa.

Current tools for combating malaria, such as artemisinin-combination therapy and increasing coverage of long-lasting insecticide bednets can result in major reductions in Plasmodium falciparum malaria transmission and the associated disease burden in Africa. Furthermore, if such interventions can be rolled out to achieve a comprehensive and sustained intervention program, a parasite prevalence threshold of 1% may be achievable in areas where there is a low- to moderate transmission of malaria and where mosquitoes mainly rest indoors.

These are the findings from a modeling study by Jamie Griffin and colleagues from Imperial College London and the London School of Hygiene and Tropical Medicine, published in PLoS Medicine.

The authors reached these conclusions by developing a mathematical simulation model for P. falciparum transmission in Africa, which incorporated three major types of mosquito, parasite prevalence data in 34 areas of Africa with differing P. falciparum malaria transmission levels, and the effect of switching to artemisinin-combination therapy and increasing coverage of long-lasting insecticide treated bednets. Then the authors explored the impact on transmission of continued roll-out of long-lasting insecticide treated bednets, additional rounds of indoor residual spraying, mass screening and treatment and a future vaccine in six representative settings with varying transmission intensity with the aim of reaching a realistic target of 80% coverage. The model predicted some success in low and moderate transmission settings but in high-transmission areas and those in which mosquitoes are mainly outdoor-resting, additional new tools that target outdoor-biting mosquitoes and substantial social improvements will be required as higher levels of intervention coverage are unrealistic.

The authors say, "Our model is necessarily a simplification of the more complex dynamics underlying malaria transmission and control, so numerical results should be interpreted more as providing intuitive insight into potential scenarios than as firm predictions of what might happen in a given setting."

This work was funded by the Bill & Melinda Gates Vaccine Modeling Initiative, the UK Medical Research Council, Microsoft Research, and the TransMalariaBloc European Commission FP7 Collaborative project (HEALTH-F3-2008-223736). TDH is funded by an Imperial College Junior Research Fellowship.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Griffin JT, Hollingsworth TD, Okell LC, Churcher TS, White M, et al. Reducing Plasmodium falciparum Malaria Transmission in Africa: A Model-Based Evaluation of Intervention Strategies. PLoS Medicine, 2010; 7 (8): e1000324 DOI: 10.1371/journal.pmed.1000324

Cite This Page:

Public Library of Science. "High malaria transmission areas remain a problem for elimination." ScienceDaily. ScienceDaily, 12 August 2010. <www.sciencedaily.com/releases/2010/08/100810203453.htm>.
Public Library of Science. (2010, August 12). High malaria transmission areas remain a problem for elimination. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2010/08/100810203453.htm
Public Library of Science. "High malaria transmission areas remain a problem for elimination." ScienceDaily. www.sciencedaily.com/releases/2010/08/100810203453.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins