Featured Research

from universities, journals, and other organizations

New model may simplify high-dose radiosurgery planning

Date:
September 11, 2010
Source:
Ohio State University Medical Center
Summary:
There is yet no straightforward way to determine the optimal dose level and treatment schedules for high-dose radiation therapies such as stereotactic radiation therapy, which is used to treat brain and lung cancer, or for high-dose brachytherapy for prostate and other cancers. Radiation oncology researchers may have solved the problem with a new mathematical model called the Generalized LQ (gLQ) Model that encompasses all dose levels and schedules.

There is yet no straightforward way to determine the optimal dose level and treatment schedules for high-dose radiation therapies such as stereotactic radiation therapy, which is used to treat brain and lung cancer, or for high-dose brachytherapy for prostate and other cancers.

Related Articles


Radiation oncologists at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) may have solved the problem by developing a new mathematical model that encompasses all dose levels.

Typically, radiation therapy for cancer is given in daily, low doses spread over many weeks. Oncologists often calculate the schedules for these fractionated, low-dose treatment courses using a mathematical model called the linear-quadratic (LQ) Model. The same calculation model is used to evaluate radiation response, interpret clinical data and guide clinical trials.

"Unfortunately the LQ Model doesn't work well for high-dose radiation therapy," says co-author Dr. Nina Mayr, professor of radiation oncology at the OSUCCC-James. "Our study resolves this problem by modifying the current method to develop the Generalized LQ (gLQ) Model that covers all dose levels and schedules."

If verified clinically, the Generalized gLQ Model could guide the planning of dose and schedules needed for the newer radiosurgery and stereotactic radiation therapy and high-dose brachytherapy procedures that are increasingly used for cancer patients, she says.

"Developing proper radiation dose schedules for these promising high-dose treatments is very challenging," Mayr says. "Typically, it involves phase I dose-finding studies and a long, cumbersome process that allows only gradual progression from the pre-clinical and clinical trial stages to broader clinical practice."

The new gLQ Model could allow oncologists to design radiation dose schedules more efficiently, help researchers conduct clinical trials for specific cancers more quickly and make these high-dose therapies available to cancer patients much sooner, Mayr says.

Fractionated low-dose therapy causes cumulative damage to tumor cells during the many weeks of exposure, while causing minimal damage to hardier normal cells. Patients, however, must return repeatedly to the hospital for many weeks to complete their treatment.

High-dose therapy has become possible because of advances in computer and radiation technology. It uses multiple beams of radiation that conform tightly to a tumor's shape. They converge on the cancer to deliver higher total radiation levels, while sparing normal tissues. This kills more tumor cells per treatment, so far fewer treatments are needed overall.

The new study, published recently in the journal Science Translational Medicine, tested the gLQ Model in cell and animal models, and is expected to be evaluated soon in clinical trials.

"Our Generalized LQ Model determines appropriate radiation levels across the entire wide spectrum of doses, from low and high, and from many to very few treatments, which is a new approach," Mayr says.

Note: First author Dr. Jian Z. Wang, director of the OSUCCC-James Tumor Response Modeling Laboratory in Radiation Oncology, passed away unexpectedly in June 2010. He was largely responsible for developing the Generalized gLQ Model.

Other Ohio State researchers involved in this study were Drs. Zhibin Huang, Simon S. Lo and William T.C. Yuh.


Story Source:

The above story is based on materials provided by Ohio State University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Z. Wang, Z. Huang, S. S. Lo, W. T. C. Yuh, N. A. Mayr. A Generalized Linear-Quadratic Model for Radiosurgery, Stereotactic Body Radiation Therapy, and High-Dose Rate Brachytherapy. Science Translational Medicine, 2010; 2 (39): 39ra48 DOI: 10.1126/scitranslmed.3000864

Cite This Page:

Ohio State University Medical Center. "New model may simplify high-dose radiosurgery planning." ScienceDaily. ScienceDaily, 11 September 2010. <www.sciencedaily.com/releases/2010/09/100902173301.htm>.
Ohio State University Medical Center. (2010, September 11). New model may simplify high-dose radiosurgery planning. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/09/100902173301.htm
Ohio State University Medical Center. "New model may simplify high-dose radiosurgery planning." ScienceDaily. www.sciencedaily.com/releases/2010/09/100902173301.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Computers & Math News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

FCC Forces T-Mobile To Alert Customers Of Data Throttling

FCC Forces T-Mobile To Alert Customers Of Data Throttling

Newsy (Nov. 25, 2014) T-Mobile and the FCC have reached an agreement requiring the company to alert customers when it throttles their data speeds. Video provided by Newsy
Powered by NewsLook.com
Symantec Uncovers Sophisticated Spying Malware Regin

Symantec Uncovers Sophisticated Spying Malware Regin

Newsy (Nov. 24, 2014) A Symantec white paper reveals details about Regin, a spying malware of unusual complexity which is believed to be state-sponsored. Video provided by Newsy
Powered by NewsLook.com
How to Keep Your Android Device Safe This Holiday Season

How to Keep Your Android Device Safe This Holiday Season

Howdini (Nov. 24, 2014) Protect yourself against malware and hackers, especially during the hectic online shopping season. Mobile device security makes a great holiday gift and protects your loved ones from cyber attacks and identity theft. Video provided by Howdini
Powered by NewsLook.com
How to Keep You and Your Family's Identitiy Safe Online This Holiday Season

How to Keep You and Your Family's Identitiy Safe Online This Holiday Season

Howdini (Nov. 24, 2014) The hectic holiday season is a prime time for online identity theft, so make sure you’re protected.Be cautious when shopping online Internet security software makes a great holiday gift and protects your loved ones from cyber attacks and identity theft. Video provided by Howdini
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins