Featured Research

from universities, journals, and other organizations

New treatment options target underlying causes of childhood obsessive-compulsive and Tourette's disorders

Date:
September 13, 2010
Source:
Mary Ann Liebert, Inc.
Summary:
Pediatric-onset obsessive compulsive disorder (OCD) and Tourette's disorder (TD) share similarities in their underlying genetic and environmental factors, psychiatric features, and treatment methods. Advances in understanding the neurobiological basis of these disorders and discovering new and more effective therapies are highlighted in a special issue on OCD and TD in Journal of Child and Adolescent Psychopharmacology.

Pediatric-onset obsessive compulsive disorder (OCD) and Tourette's disorder (TD) share similarities in their underlying genetic and environmental factors, psychiatric features, and treatment methods. Advances in understanding the neurobiological basis of these disorders and discovering new and more effective therapies are highlighted in a special issue on OCD and TD in Journal of Child and Adolescent Psychopharmacology, a peer-reviewed journal published by Mary Ann Liebert, Inc.

The entire issue is available free online at www.liebertpub.com/cap

Guest editors Barbara J. Coffey, MD, MS, from the New York University Child Study Center, and Judith Rapoport, MD Chief, Child Psychiatry Branch, National Institute of Mental Health, NIH describe the current reality of these challenging neuropsychiatric disorders in the editorial, "Obsessive-Compulsive Disorder and Tourette's Disorder: Where Are We Now?" They conclude that "studies are still few, and validated predictors, moderators and mediators of treatment response are still very much needed."

Riluzole, a drug approved for treating patients with the neurodegenerative disease amyotrophic lateral sclerosis (ALS), has shown promise in psychiatric conditions such as OCD in children and is currently being studied in a clinical trial that will assess its efficacy and side effects in young people who have not benefited from standard-of-care treatments. Paul Grant, Jane Song, and Susan Swedo from the National Institute of Mental Health (Bethesda, MD) describe the potential for riluzole to help control OCD symptoms based on its ability to block the release of glutamate from nerve cells. Although the drug appears to be generally well tolerated at therapeutic doses, cases of pancreatitis in children, an uncommon adverse effect associated with riluzole use, are cause for concern, as the authors report in the article, "Review of the Use of the Glutamate Antagonist Riluzole in Psychiatric Disorders and a Description of Recent Use in Childhood Obsessive-Compulsive Disorder."

James Leckman, MD, and colleagues from Yale University (New Haven, CT) and University of Groningen (The Netherlands) present a review of the literature describing the current understanding of how various brain circuits, neural networks, and chemical neurotransmitters are involved in causing the motor and vocal tics associated with Tourette's disorder. In the article, "Neurobiological Substrates of Tourette's Disorder," the authors propose that improved imaging technology will help identify specific brain circuits that might be targets for new drug development.

Tanya Murphy, MD, Roger Kurlan, MD, and James Leckman, MD, from University of South Florida (Tampa), Overlook Hospital (Summit, NJ), and Yale University School of Medicine, explore the suspected role of infectious agents and, in particular, Group A Streptococcus, in OCD and TD. In the article "The Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward," they review the evidence that points to pediatric autoimmune neuropsychiatric disorders associated with Streptococcus, called PANDAS, discuss the ongoing controversy regarding infectious triggers of these disorders, and call for the National Institutes of Health to convene a panel of experts to explore new treatment opportunities based on an infectious disease mechanism.

"We are proud that two of our Associate Editors and two of the nation's leading experts, Drs. Judy Rapoport and Barbara Coffey, have edited this important issue on disorders that affect millions of children and adolescents in our country today," says Harold S. Koplewicz, MD, Editor-in-Chief of Journal of Child and Adolescent Psychopharmacology, and President, Child Mind Institute, New York, NY, and Director of the Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

Mary Ann Liebert, Inc.. "New treatment options target underlying causes of childhood obsessive-compulsive and Tourette's disorders." ScienceDaily. ScienceDaily, 13 September 2010. <www.sciencedaily.com/releases/2010/09/100909091422.htm>.
Mary Ann Liebert, Inc.. (2010, September 13). New treatment options target underlying causes of childhood obsessive-compulsive and Tourette's disorders. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2010/09/100909091422.htm
Mary Ann Liebert, Inc.. "New treatment options target underlying causes of childhood obsessive-compulsive and Tourette's disorders." ScienceDaily. www.sciencedaily.com/releases/2010/09/100909091422.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins